{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:40:58Z","timestamp":1773013258673,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","award":["104.01\u20102021.43"],"award-info":[{"award-number":["104.01\u20102021.43"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Zanthoxylum avicennea<\/jats:italic>\n                    (Rubiaceae family) has been used in traditional medicine. Study on the leaves of\n                    <jats:italic>Z. avicennea<\/jats:italic>\n                    resulted in four undescribed compounds, zanthoavicenneas A\u2013D (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    ), along with twelve known ones (\n                    <jats:bold>5<\/jats:bold>\n                    \u2013\n                    <jats:bold>16<\/jats:bold>\n                    ). Their structures were elucidated by spectroscopic techniques, including HR\u2010ESI\u2010MS, 1D and 2D NMR spectroscopy. The absolute configurations of compounds\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    were further determined by ECD spectroscopy. Among the known isolates, the complete NMR data assignments for compound\n                    <jats:bold>5<\/jats:bold>\n                    were also reported for the first time. In addition, compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    , and\n                    <jats:bold>5<\/jats:bold>\n                    exhibited favorable inhibitory effects on NO production in LPS\u2010activated RAW264.7 macrophages, showing IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 22.73\u00a0\u00b1\u00a01.12, 37.61\u00a0\u00b1\u00a01.25, and 28.96\u00a0\u00b1\u00a01.66\u00a0\u00b5M, respectively, as compared to a well\u2010known NO inhibitor, dexamethasone (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a013.12\u00a0\u00b1\u00a00.92\u00a0\u00b5M). The remaining compounds displayed moderate to weak inhibitory activity, showing IC\n                    <jats:sub>50<\/jats:sub>\n                    values from 57.20\u00a0\u00b1\u00a01.50 to 84.56\u00a0\u00b1\u00a02.18\u00a0\u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501654","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T18:45:37Z","timestamp":1753469137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Four Undescribed Compounds From the Leaves of\n                    <i>Zanthoxylum avicennea<\/i>\n                    and Their NO Inhibitory Activity"],"prefix":"10.1002","volume":"22","author":[{"given":"Bui Thi Mai","family":"Anh","sequence":"first","affiliation":[{"name":"Basic Science Department University of Transport and Communications  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duong Thi","family":"Dung","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Thuy","family":"Nga","sequence":"additional","affiliation":[{"name":"Basic Science Department University of Transport and Communications  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui Thi Nha","family":"Trang","sequence":"additional","affiliation":[{"name":"Basic Science Department Hanoi University of Natural Resources and Environment  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi","family":"Mai","sequence":"additional","affiliation":[{"name":"Basic Science Department University of Transport and Communications  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan","family":"Van Kiem","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Phuong","family":"Thao","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui Huu","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tax.12543"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115895"},{"key":"e_1_2_9_4_1","first-page":"179","article-title":"Dictionary of Medicinal Plants in Vietnam","volume":"2","author":"Chi V. 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