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Ethanol\u2010extracted ALLEs were analysed using GC\u2013MS to identify major phytoconstituents. Thunbergol, lupenone and squalene were identified as key bioactive compounds. ADMET profiling using SwissADME and pkCSM revealed favourable pharmacokinetic and safety profiles, particularly for thunbergol and lupenone. Network pharmacology analysis indicated potential modulation of the NF\u2010\u03baB signalling pathway, a key mediator in neuroinflammation. Molecular docking and dynamic simulations confirmed strong binding affinity and stability of active compounds with target proteins. An in vivo CIPN model was established in mice to validate these findings. Animals were administered ALLEs (200 and 400\u00a0mg\/kg, po) and compared with a standard group receiving gabapentin (100\u00a0mg\/kg, po). Behavioural assessments (tail flick, cold allodynia and hot plate tests) significantly reduced neuropathic pain symptoms. Biochemical assays showed decreased levels of inflammatory cytokines (TNF\u2010\u03b1, IL\u20101\u03b2 and IL\u20106), and histopathological analysis of sciatic nerves revealed reduced inflammation and preserved axonal integrity. In conclusion, ALLEs exhibits significant neuroprotective effects against cisplatin\u2010induced neuropathic pain, primarily through modulation of the NF\u2010\u03baB pathway. These findings support further exploration of\n                    <jats:italic>A. lebbeck<\/jats:italic>\n                    as a natural therapeutic candidate for CIPN management.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501656","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:44:56Z","timestamp":1758383096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuroprotective Role of\n                    <i>Albizia lebbeck<\/i>\n                    Leaves Against Cisplatin\u2010Induced Neuropathic Pain via Modulating NF\u2010\u03baB Signalling Pathway"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9279-5687","authenticated-orcid":false,"given":"Sk","family":"Irfan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Health &amp; Medical Sciences Adamas University  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4796-6016","authenticated-orcid":false,"given":"Sourav","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Health &amp; 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