{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:02:30Z","timestamp":1775890950344,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of novel O\u2010prenylated, O\u2010glycosylated, and O\u2010benzylated phenazine derivatives were efficiently synthesized in good yields from 5\u2010O\u2010methylembelin. Structures of these derivatives were confirmed by infrared, proton, and carbon\u201013 NMR, and mass spectral analysis. Antimicrobial evaluation against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    suggested several derivatives possessed significant activity. Specifically, compounds\n                    <jats:bold>4e<\/jats:bold>\n                    ,\n                    <jats:bold>6e<\/jats:bold>\n                    , and\n                    <jats:bold>7e<\/jats:bold>\n                    exhibited considerable antibacterial activity, inhibiting zones of up to 12\u00a0mm, whereas compounds\n                    <jats:bold>4c<\/jats:bold>\n                    ,\n                    <jats:bold>4d<\/jats:bold>\n                    ,\n                    <jats:bold>6e<\/jats:bold>\n                    , and\n                    <jats:bold>7c<\/jats:bold>\n                    possessed moderate antifungal activity (12\u201313\u00a0mm), compared to fluconazole (23\u00a0mm). Structure\u2013activity relationship analysis proposes the integration of halog\u00a0substituents and glycosylation leads to increased potency by increasing lipophilicity and interacting better with membranes. Molecular docking studies also confirmed these findings, revealing suitable binding affinities of the active compounds with microbial target proteins. Overall, this work offers new phenazine scaffolds potential candidates for the development of antibacterial and antifungal drugs.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501658","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T18:19:17Z","timestamp":1765304357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of O\u2010Prenylated O\u2010Glycosylated and O\u2010Benzylated Phenazines Derivatives and Their Antimicrobial and Molecular Docking Studies"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6529-6546","authenticated-orcid":false,"given":"T.","family":"Karunakar","sequence":"first","affiliation":[{"name":"Department of Chemistry Satavahana University Karimnagar Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-8502","authenticated-orcid":false,"given":"J.","family":"Prashanth","sequence":"additional","affiliation":[{"name":"Department of Physics Kakatiya University Vidyaranyapuri Warangal Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2862-9316","authenticated-orcid":false,"given":"K. Raghava","family":"Raju","sequence":"additional","affiliation":[{"name":"Government Junior College  Hanamkonda India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-7731","authenticated-orcid":false,"given":"B. Venkat Ram","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Physics Kakatiya University Vidyaranyapuri Warangal Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8808-7636","authenticated-orcid":false,"given":"M. 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