{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:41:11Z","timestamp":1773013271923,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Previous studies on Carissa carandas have demonstrated that C. carandas contains various triterpenoids exhibiting significant cytotoxic activities against cancer cells. In the current study, two novel pentacyclic triterpenoids (\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    ), together with six known triterpenoids (\n                    <jats:bold>3\u20138<\/jats:bold>\n                    ), were isolated from the leaves of C. carandas. The structures of these new compounds were unequivocally elucidated by high\u2010resolution electrospray ionization mass spectrometry and one\u2010\/two\u2010dimensional nuclear magnetic resonance data. All the isolates were evaluated for their cytotoxic effects against four cancer cell lines, including CNE1, CNE2, HONE\u20101, and CAL27. Among them, compound\n                    <jats:bold>1<\/jats:bold>\n                    was found to display significant cytotoxicity toward CNE1 and HONE\u20101 cancer cells with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.31\n                    <jats:italic>\u00b1 0.71<\/jats:italic>\n                    and\n                    <jats:italic>3.87 \u00b1 0.35 \u00b5<\/jats:italic>\n                    M, respectively.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501660","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T21:50:06Z","timestamp":1752357006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Triterpenoids From the Leaves of Carissa carandas With Their Cytotoxicities on Cancer Cells"],"prefix":"10.1002","volume":"22","author":[{"given":"Jia\u2010Yuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Graduate School of Dental Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Fourth Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Hoshika","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dental Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiharu","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dental Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiko","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dental Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Peripheral Vascular Diseases The First Affiliated Hospital of Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7313-6470","authenticated-orcid":false,"given":"Atsushi","family":"Tomokiyo","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dental Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13091037"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jafr.2024.101417"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13328"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0815-4832"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.03.036"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2024.2437548"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2023.2232082"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.03.051"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)91126-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2020.1791098"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.1886101"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2012.11.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-021-01588-w"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2020.01.004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b00659"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2025.01.006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2015.1075526"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2016.06.009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2023.113853"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010196"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401029"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.4c01257"}],"container-title":["Chemistry &amp; 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