{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:18:50Z","timestamp":1788470330074,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lipoprotein metabolism is regulated by several key proteins, notably proprotein convertase subtilisin\/kexin type 9 (PCSK9) and the low\u2010density lipoprotein receptor (LDLR).\n                    <jats:italic>Punica granatum<\/jats:italic>\n                    peel extract has been reported to exhibit lipid\u2010lowering properties; however, the underlying mechanisms of its action on lipid metabolism remain insufficiently characterized. In this study, the hydroethanolic extract of\n                    <jats:italic>P. granatum<\/jats:italic>\n                    peel (PPE) was found to be rich in phenolic compounds and exhibited strong antioxidant activity. Characterization by liquid chromatography coupled with diode array and multiple\u2010stage mass spectrometry (LC\u2010DAD\u2010MS\n                    <jats:italic>\u207f<\/jats:italic>\n                    ) identified punicalin, pedunculagin I, and galloyl\u2010HHDP\u2010hexose as the main constituents. Similar to statin treatment, PPE exposure significantly upregulated PCSK9 and LDLR protein expression in cultured cells compared to untreated controls, though the effect was less pronounced than that observed with statins. These findings suggest that phenolic\u2010rich PPE may serve as a promising natural source for the development of therapeutic agents aimed at preventing cardiovascular diseases.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501668","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T19:50:35Z","timestamp":1762631435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antioxidant Activity and Potential Cholesterol Modulating Effect of\n                    <i>Punica granatum<\/i>\n                    L. Peel Hydroethanolic Extract"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-5621","authenticated-orcid":false,"given":"Raja","family":"Chaaba","sequence":"first","affiliation":[{"name":"LR12ES05, \u201cNutrition\u2010Functional Foods &amp; Health\u201d (NAFS), Faculty of Medicine University of Monastir  Monastir Tunisia"},{"name":"Higher School of Health Sciences and Technologies University of Sousse  Sousse Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"Nakbi","sequence":"additional","affiliation":[{"name":"LR12ES05, \u201cNutrition\u2010Functional Foods &amp; Health\u201d (NAFS), Faculty of Medicine University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanen","family":"Jrah","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Amri","sequence":"additional","affiliation":[{"name":"LR12ES05, \u201cNutrition\u2010Functional Foods &amp; 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