{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:59:34Z","timestamp":1775890774371,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of indoline hybrids with amide and sulfonamide functionalities containing furan (\n                    <jats:bold>6a\u2013k<\/jats:bold>\n                    ) and pyrrole (\n                    <jats:bold>13a\u2013k<\/jats:bold>\n                    ) were synthesized through a multistep process with good yield. The final compounds were purified using reverse\u2010phase flash chromatography and characterized by FTIR,\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, LC\u2013MS, and elemental analysis. These compounds were evaluated for their in vitro antibacterial activity against various bacterial strains, including\n                    <jats:italic>Bacillus<\/jats:italic>\n                    subtilis,\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    aureus,\n                    <jats:italic>Pseudomonas<\/jats:italic>\n                    aeruginosa, and\n                    <jats:italic>Escherichia<\/jats:italic>\n                    coli. Among the compounds tested, compound\n                    <jats:bold>6k<\/jats:bold>\n                    and\n                    <jats:bold>13e<\/jats:bold>\n                    exhibited the highest activity, demonstrating potency compared to the standard antibiotic drugs utilized. The antifungal activity of these newly synthesize compounds was also assessed in vitro against\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    niger and\n                    <jats:italic>Candida<\/jats:italic>\n                    albicans, the results emphasized that compounds\n                    <jats:bold>6k<\/jats:bold>\n                    and\n                    <jats:bold>13e<\/jats:bold>\n                    displayed the highest activity, compared to the standard antifungal drug nystatin. Furthermore, in silico investigations of compounds\n                    <jats:bold>6a\u2013k<\/jats:bold>\n                    and\n                    <jats:bold>13a\u2013k<\/jats:bold>\n                    with E. coli DNA gyrase, using molecular docking and molecular dynamics simulations, revealed exceptional binding affinity of these derivatives to the protein's active site. Additionally, in silico ADMET analysis indicated favorable pharmacokinetic properties with no major toxicity concerns, highlighting their potential as effective antimicrobial agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501677","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:59:23Z","timestamp":1764093563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Synthesis, In Vitro Antimicrobial Profiling and In Silico Investigation of Furan\u2010 and Pyrrole\u2010Linked Indoline Hybrids Incorporating Amide and Sulfonamide Functionalities"],"prefix":"10.1002","volume":"23","author":[{"given":"Ajay J.","family":"Jani","sequence":"first","affiliation":[{"name":"Department of Chemistry Atmiya University, Yogidham Gurukul  Rajkot Gujarat India"},{"name":"Piramal Pharma Solution  Ahmedabad Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4047-5687","authenticated-orcid":false,"given":"Jignesh H.","family":"Kamdar","sequence":"additional","affiliation":[{"name":"In\u2010Silico Lab, Department of Microbiology, School of Science RK University  Rajkot Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-3940","authenticated-orcid":false,"given":"Satishkumar D.","family":"Tala","sequence":"additional","affiliation":[{"name":"Department of Chemistry Atmiya University, Yogidham Gurukul  Rajkot Gujarat India"},{"name":"SNJ Labs Pvt. 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