{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:02:01Z","timestamp":1775890921154,"version":"3.50.1"},"reference-count":79,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aluminum chloride (AlCl\n                    <jats:sub>3<\/jats:sub>\n                    ) is a known reproductive toxicant that impairs spermatogenesis and disrupts hormonal balance. Natural antioxidants have emerged as promising candidates to counteract such effects.\n                    <jats:italic>Cynomorium coccineum<\/jats:italic>\n                    (\n                    <jats:italic>Cc<\/jats:italic>\n                    ), a parasitic medicinal plant rich in polyphenols and flavonoids, possesses strong antioxidant activity but remains underexplored in the context of male fertility. This study evaluated the protective effects of\n                    <jats:italic>Cc<\/jats:italic>\n                    aqueous extract (CCAE) against AlCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced reproductive toxicity in adult male Wistar rats. Phytochemical characterization of CCAE via UPLC\u2013MS\/MS identified 14 bioactive compounds, with gallic acid as the major constituent. Total phenolic and flavonoid content, along with in vitro antioxidant assays, confirmed potent activity (2,2\u2010diphenyl\u20101\u2010picrylhydrazyl [DPPH] IC\n                    <jats:sub>50<\/jats:sub>\n                    : 54.52\u00a0\u00b1\u00a00.84\u00a0\u00b5g\/mL; reducing power: 196.01\u00a0\u00b1\u00a01.05\u00a0\u00b5g\/mL). Acute toxicity testing established safety up to 2000\u00a0mg\/kg. Rats were assigned to four groups to assess CCAE's dose\u2010dependent effects following AlCl\n                    <jats:sub>3<\/jats:sub>\n                    exposure. AlCl\n                    <jats:sub>3<\/jats:sub>\n                    significantly reduced sperm quality, testosterone levels, and gonadosomatic index and altered testicular histoarchitecture. CCAE administration reversed these impairments, improving hormonal balance, sperm parameters, and tissue structure. These findings highlight the antioxidant\u2010mediated protective role of\n                    <jats:italic>Cc<\/jats:italic>\n                    against AlCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced reproductive toxicity and support its potential as a natural therapeutic agent for male fertility enhancement.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501709","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:55:06Z","timestamp":1770720906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Characterization and Reproductive Protective Potential of\n                    <i>Cynomorium coccineum<\/i>\n                    Against Aluminum\u2010Induced Toxicity in Rats"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0812-6367","authenticated-orcid":false,"given":"Yousra","family":"Toualbia","sequence":"first","affiliation":[{"name":"Laboratory of Biology, Environment, and Health Faculty of Natural and Life Sciences University of El Oued  El Oued Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1091-8176","authenticated-orcid":false,"given":"Farah","family":"Ramdane","sequence":"additional","affiliation":[{"name":"Laboratory of Biology, Environment, and Health Faculty of Natural and Life Sciences University of El Oued  El Oued Algeria"},{"name":"Biogeochemistry Laboratory in Desert environments Faculty of Natural and Life Sciences Kasdi\u2010Merbah University  Ouargla Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8925-3863","authenticated-orcid":false,"given":"Benziane","family":"Mohammed Yassine","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Microbiology in Food, Biomedical, and Environment (LAMAABE), Department of Biology, Faculty of Sciences of Nature, Life, Earth, and Universe Abou Bekr Belka\u00efd University of Tlemcen  Tlemcen Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7227","authenticated-orcid":false,"given":"Mustafa Abdullah","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy University Science and Technology Research and Application Center  Diyarbakir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-2054","authenticated-orcid":false,"given":"Oguz","family":"Cakir","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Faculty of Health Sciences University Science and Technology Research and Application Center  Diyarbakir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-4826","authenticated-orcid":false,"given":"Enes","family":"Arica","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Dicle University  Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6138-4461","authenticated-orcid":false,"given":"Hajer","family":"Ziadi","sequence":"additional","affiliation":[{"name":"Laboratory of Sciences and Technics of Animal Production Faculty of Natural and Life Sciences (LSTAP) University Abdelhamid ibn Badis of Mostaganem  Mostaganem Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"2834","article-title":"A Review on Some Causes of Male Infertility","volume":"920","author":"Olayemi F. 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