{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:51:27Z","timestamp":1780365087495,"version":"3.54.1"},"reference-count":66,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Eugenol\u2010derived compounds have recently garnered significant attention in medicinal chemistry as a novel class of agents with potential as drug candidates for diverse therapeutic applications. This study aims to synthesize novel eugenol\u2013amide hybrids and evaluate their antimicrobial response against various pathogenic fungal (\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    ATCC 10231) and bacterial strains (\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ATCC 25922,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    CIP A22,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ATCC 25923). The synthesized hybrids were thoroughly characterized using infrared spectroscopy,\n                    <jats:sup>1<\/jats:sup>\n                    H\/\n                    <jats:sup>13<\/jats:sup>\n                    C nuclear magnetic resonance (NMR), and mass spectrometry. Results reveal that compounds\n                    <jats:bold>4c<\/jats:bold>\n                    ,\n                    <jats:bold>4k<\/jats:bold>\n                    , and\n                    <jats:bold>4n<\/jats:bold>\n                    exhibit moderate antibacterial activity, with minimum inhibitory concentration (MIC) values spanning 3.9\u201331.25\u00a0\u00b5g\/mL. Compounds\n                    <jats:bold>4c<\/jats:bold>\n                    and\n                    <jats:bold>4k<\/jats:bold>\n                    showed the most potent antifungal activity against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    (MIC value of 3.9\u00a0\u00b5g\/mL), surpassing that of fluconazole (MIC value of 7.8\u00a0\u00b5g\/mL), whereas derivatives\n                    <jats:bold>4e<\/jats:bold>\n                    ,\n                    <jats:bold>4f<\/jats:bold>\n                    ,\n                    <jats:bold>4i<\/jats:bold>\n                    , and\n                    <jats:bold>4j<\/jats:bold>\n                    exhibited significant antifungal effects (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) comparable to fluconazole. In silico analysis indicates that most derivatives possess favorable predicted pharmacokinetic properties and low toxicity. Furthermore, molecular docking studies revealed enhanced binding free energy scores for the top compounds, whereas molecular dynamics simulations were performed to evaluate the stability of the resulting protein\u2013ligand complexes.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501712","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T19:31:47Z","timestamp":1761334307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis, Characterization, and Biological Evaluations of Eugenol\u2013Amide Hybrids as Promising Antimicrobial Agents: Experimental and Computational Approaches"],"prefix":"10.1002","volume":"22","author":[{"given":"Ayoub","family":"Ouaddi","sequence":"first","affiliation":[{"name":"Bioorganic Chemistry Team, Faculty of Science Choua\u00efb Doukkali University  El Jadida Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Zefzoufi","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Team, Faculty of Science Choua\u00efb Doukkali University  El Jadida Morocco"},{"name":"Laboratory of Sustainable Development and Health Research, Faculty of Sciences and Techniques Cadi Ayyad University  Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Khedraoui","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik Hassan II University of Casablanca  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0768-9686","authenticated-orcid":false,"given":"Bouchra","family":"Es\u2010Sounni","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Team, Faculty of Science Choua\u00efb Doukkali University  El Jadida Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-5101","authenticated-orcid":false,"given":"Samir","family":"Chtita","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik Hassan II University of Casablanca  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkrim","family":"Mouzdahir","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Team, Faculty of Science Choua\u00efb Doukkali University  El Jadida Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noureddine","family":"Mazoir","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Team, Faculty of Science Choua\u00efb Doukkali University  El Jadida Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Benharref","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Chemistry, Faculty of Sciences Semlalia Cadi Ayyad University  Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafida","family":"Bouamama","sequence":"additional","affiliation":[{"name":"Laboratory of Sustainable Development and Health Research, Faculty of Sciences and Techniques Cadi Ayyad University  Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabiaa","family":"Fdil","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Team, Faculty of Science Choua\u00efb Doukkali University  El Jadida Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0732-6524","authenticated-orcid":false,"given":"Mohamed","family":"Bakhouch","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Team, Faculty of Science Choua\u00efb Doukkali University  El Jadida Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10101310"},{"key":"e_1_2_9_3_1","first-page":"3954","article-title":"The Potential of Ayurvedic Medicinal Plants for Prevention and Therapeutic Treatment of Covid\u201019: A Review Article","volume":"11","author":"Muderawan I. 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