{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:46:48Z","timestamp":1775998008221,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015518","name":"University of Nizwa","doi-asserted-by":"publisher","award":["UoN\/53\/IF\/25"],"award-info":[{"award-number":["UoN\/53\/IF\/25"]}],"id":[{"id":"10.13039\/501100015518","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In the current findings, the essential oils (EOs) from\n                    <jats:italic>Boswellia sacra<\/jats:italic>\n                    (\n                    <jats:italic>Burseraceae<\/jats:italic>\n                    ) plant's stem (BSS) and leaves (BSL) are analyzed via gas chromatography\u2013mass spectrometry (GC\u2013MS) for the first time, and their multiple biological properties were evaluated. Fifty\u2010four (54) compounds were identified in both parts, containing 93.24% of the stem (BSS) and 97.76% of the leaf (BSL) oils. The highest amount of t\u2010muurolol was found in leaf oil (17.41 \u00b1 1.58%), while t\u2010cadinol was the second abundant compound found in leaves (12.96 \u00b1 1.02%). Significant potential was shown by leaves\u2019 oil having IC\n                    <jats:sub>50<\/jats:sub>\n                    of 88.7 \u00b1 0.36\u00a0\u00b5g\/mL than stem (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 92.2 \u00b1 0.48) against breast cancer (MDA\u2010MB\u2010231) cells. Significant antidiabetic potential was observed by stem's EO (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 1.54 \u00b1 0.10\u00a0\u00b5g\/mL), followed by leaves (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 2.06 \u00b1 0.13\u00a0\u00b5g\/mL), while the stem (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 77.08 \u00b1 1.15\u00a0\u00b5g\/mL) exhibited higher human carbonic anhydrase\u2010II (CA\u2010II) inhibitory activity than leaves (99.93 \u00b1 1.36). Furthermore, the stem oil showed significant antimicrobial activity against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    with minimum inhibitory concentration (MIC) values of 4.168 \u00b1 0.24\u00a0mg\/mL and 16.675 \u00b1 0.46\u00a0mg\/mL, respectively. Furthermore, the binding modes of common compounds found in the stem and leaf oils were forecasted at the molecular level by docking them into the binding site of \u03b1\u2010glucosidase and CA\u2010II anhydrase, which correlates with the in vitro results. The predicted physicochemical profiling of the scaffolds further reflects their acceptable properties, which depict their ability to become drug\u2010like candidates.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501719","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:59:44Z","timestamp":1772989184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemo Profiling and In Vitro and In Silico Exploration of Essential Oils From Stem and Leaves of\n                    <i>Boswellia sacra<\/i>\n                    Fluck"],"prefix":"10.1002","volume":"23","author":[{"given":"Usama","family":"Qayum","sequence":"first","affiliation":[{"name":"Natural and Medical Sciences Research Center University of Nizwa  Nizwa Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faizullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Natural and Medical Sciences Research Center University of Nizwa  Nizwa Oman"},{"name":"Department of Pharmacy Abdul Wali Khan University  Mardan Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib","family":"Al\u2010Jahdhami","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences Oman College of Health Sciences  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Ullah","sequence":"additional","affiliation":[{"name":"Natural and Medical Sciences Research Center University of Nizwa  Nizwa Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atta","family":"Ullah","sequence":"additional","affiliation":[{"name":"Natural and Medical Sciences Research Center University of Nizwa  Nizwa Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sobia Ahsan","family":"Halim","sequence":"additional","affiliation":[{"name":"Natural and Medical Sciences Research Center University of Nizwa  Nizwa Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajmal","family":"Khan","sequence":"additional","affiliation":[{"name":"Natural and Medical Sciences Research Center University of Nizwa  Nizwa Oman"},{"name":"Department of Chemical and Biological Engineering, College of Engineering Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah M. 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