{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:57:45Z","timestamp":1785488265429,"version":"3.56.0"},"reference-count":74,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Rosa roxburghii<\/jats:italic>\n                    f. eseiosa Ku, a thornless variety of\n                    <jats:italic>Rosa roxburghii<\/jats:italic>\n                    Tratt, remains underexplored regarding the tissue\u2010specific functionality and structure\u2010activity relationships of its polysaccharides. This study systematically investigated the composition and bioactivities of polysaccharides extracted from the fruit, root, stem, and thick stem of this variant. Using gradient ethanol precipitation (40%, 60%, and 80%), polysaccharides with distinct molecular weight (M\n                    <jats:italic>\n                      <jats:sub>w<\/jats:sub>\n                    <\/jats:italic>\n                    ) profiles were obtained. All isolates were identified as acidic heteropolysaccharides with complex and tissue\u2010dependent monosaccharide compositions. Fractions precipitated with 60% and 80% ethanol exhibited lower M\n                    <jats:italic>\n                      <jats:sub>w<\/jats:sub>\n                    <\/jats:italic>\n                    s and significantly enhanced bioactivities, including potent radical scavenging capacity and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase inhibition. Notably, RREK\u2010R60, the crude polysaccharide obtained from the roots of\n                    <jats:italic>Rosa roxburghii<\/jats:italic>\n                    f. eseiosa Ku via 60% ethanol precipitation, exhibited a notable\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase inhibition rate of 92.91%. Structural analysis revealed tissue\u2010specific traits, such as the unique presence of N\u2010acetylglucosamine in fruit and root samples, along with elevated uronic acid, galactose, and arabinose content, which correlated strongly with bioactivity. These findings underscore the potential of\n                    <jats:italic>Rosa roxburghii<\/jats:italic>\n                    f. eseiosa Ku polysaccharides as functional food ingredients or anti\u2010diabetic agents. Further in vivo studies and detailed structural elucidation are warranted to fully establish their structure\u2010activity relationships.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501725","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T20:26:52Z","timestamp":1762547212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antioxidant and Hypoglycemic Activity of Polysaccharides With Different Tissues From\n                    <i>Rosa roxburghii<\/i>\n                    f. eseiosa Ku"],"prefix":"10.1002","volume":"23","author":[{"given":"Zhi\u2010Wen","family":"Wan","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua\u2010Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Guizhou Ecological Energy Vocational College  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-9471","authenticated-orcid":false,"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32374\u20106"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000711450896579X"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.01.086"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4672"},{"issue":"8","key":"e_1_2_10_6_1","first-page":"1658","article-title":"Determination of Main Active Substances Content and Antioxidant Activity in Leaves of Rosa roxburghii and Its Related Germplasms","volume":"33","author":"Zhou G. Z.","year":"2019","journal-title":"Journal of Nuclear Agricultural Sciences"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2016.08.058"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"66","article-title":"Optimization of Polysaccharide Extraction Process From Rosa sterilis by Response Surface Methodology and Its Antioxidant Activity","volume":"57","author":"Fu Y. Y.","year":"2021","journal-title":"Food and Fermentation Sciences & Technology"},{"key":"e_1_2_10_9_1","first-page":"12","article-title":"Recent Advances on Main Active Ingredients, Pharmacological Activities of Rosa roxbughii and Its Development and Utilization","author":"Wang L.","year":"2023","journal-title":"Foods"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13050772"},{"issue":"4","key":"e_1_2_10_11_1","first-page":"158","article-title":"Main Economic Characters and Important Vitamin Contents of Fruits From 22 Wild Rosa Species in China","volume":"21","author":"He Y. H.","year":"1994","journal-title":"Acta Horticulturae Sinica"},{"issue":"3","key":"e_1_2_10_12_1","first-page":"17","article-title":"Comparative Study on Fruit Characters and Nutrient Components Between Rosa roxburghii f. eseiosa Ku and Rosa roxburghii in Chongqing Area","volume":"47","author":"Li C. P.","year":"2024","journal-title":"Modern Horticulture"},{"issue":"6","key":"e_1_2_10_13_1","first-page":"47","article-title":"Content of Antioxidant Substances and Antioxidant Activity of Rosa roxburghii f. eseiosa Ku","volume":"40","author":"Xiong W.","year":"2023","journal-title":"Agricultural Technology Service"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133601"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.01.004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00349"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132807"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126199"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.315"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010022\u201001393\u20103"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120965"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.12.143"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.04.067"},{"issue":"5","key":"e_1_2_10_24_1","first-page":"297","article-title":"Optimization of Polysaccharide Extraction Process From Rosa roxburghii in Bijie Area and Difference in Polysaccharide Content and Antioxidant Activity Among Different Producing Areas","volume":"14","author":"Liu X.","year":"2023","journal-title":"Journal of Food Safety and Quality"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127955"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.01.037"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","unstructured":"L. Wang C. Chen B. Zhang et al. \"Structural Characterization of a Novel Acidic Polysaccharide fromRosa roxburghiiTratt Fruit and Its \u03b1\u2010Glucosidase Inhibitory Activity \"Food & Function 9 (2018): 3974.","DOI":"10.1039\/C8FO00561C"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.08.160"},{"issue":"5","key":"e_1_2_10_29_1","first-page":"94","article-title":"In Vitro Antioxidant Activity of Crude and Pure Polysaccharides From Rosa roxburghii","volume":"29","author":"Yang J. T.","year":"2008","journal-title":"Science and Technology of Food Industry"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.232"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO03010H"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.105125"},{"issue":"2","key":"e_1_2_10_33_1","first-page":"197","article-title":"A Modified Method for Determination of Uronic Acid and Neutral Sugar Contents in Acidic Polysaccharides","volume":"28","author":"Xu H. S.","year":"2007","journal-title":"Chinese Journal of Pharmaceutical Analysis"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.04.067"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.04.001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.04.090"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2021.100168"},{"issue":"10","key":"e_1_2_10_38_1","first-page":"170","article-title":"Optimization of Extraction Process and Structural Study of Tea Polyphenols From Camellia sinensis Leaves","author":"Yang Y. R.","year":"2024","journal-title":"Modern Chemical Research"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.05.028"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2005.10.008"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.03.092"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750\u20103841.15485"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.01.111"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2012.03.008"},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","unstructured":"Q. Yuan J. Zhang C. Xiao et al. \"Structural Characterization of a Low\u2010Molecular\u2010Weight Polysaccharide from Angelica pubescens Maxim. f. biserrata Shan et Yuan Root and Evaluation of Its Antioxidant Activity \"Carbohydrate Polymers236 (2020): 116047.","DOI":"10.1016\/j.carbpol.2020.116047"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071044"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40643-024-00729-9"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.06.028"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.09.047"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127926"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104916"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO01114K"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.12.024"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104916"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO00790J"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.02.006"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136097"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.01.011"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694\u2010021\u201001125\u2010z"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4FO01989J"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/168167a0"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/app15084215"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2022.108555"},{"issue":"7","key":"e_1_2_10_64_1","first-page":"115","article-title":"Determination of Protein Content in Stauntonia chinensis Polysaccharides by Coomassie Brilliant Blue Method","volume":"29","author":"Wang W. P.","year":"2008","journal-title":"Food Research and Development"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2023.02.008"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf501952e"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202402097"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10719\u2010016\u20109669\u2010z"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.09.051"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.04.067"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.06.054"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093880"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.06.028"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12112226"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.02.006"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202501725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202501725","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202501725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:59:28Z","timestamp":1785484768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202501725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cbdv.202501725"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202501725","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,7]]},"assertion":[{"value":"2025-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01725"}}