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The current treatment protocols, related side effects, and the increasing incidence of drug resistance limit the efficacy of conventional therapeutic strategies. Traditional medicinal constituents rich in diverse phytoconstituents offer multi\u2010target action with reduced toxicity, minimal risk of resistance, and immunomodulatory properties. Network pharmacology (NP), an integrated approach merging systems biology and computational modeling, facilitates understanding complex interactions among phytochemicals, molecular targets, and signaling pathways. Integrating modern pharmacology principles with traditional wisdom, NP provides a logical framework for developing new plant\u2010based anti\u2010TB agents and advancing adjunctive therapies. Combining protein\u2013protein interaction networks, pathway enrichment analyses, multi\u2010combinational data, and molecular docking studies offers insights into how phytoconstituents affect the immune response, block efflux pumps, and reduce resistance. This review provides a detailed analysis of NP\u2010based methods for the identification of active compounds (e.g., alkaloids, flavonoids, terpenoids, polyphenols) and their related molecular targets involved in the pathogenesis of TB, including tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), Toll\u2010like receptors (TLR), nucleotide\u2010binding oligomerization domain (NOD)\u2010like receptor, and Janus kinase\/signal transducer and activator of transcription (JAK\u2013STAT) pathway.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501727","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T08:00:57Z","timestamp":1754640057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytoconstituents and Immunological Responses in Tuberculosis: Insights Into Network Pharmacology"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3636-8257","authenticated-orcid":false,"given":"Divya","family":"Nasare","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed\u2010to\u2010be University  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-7556","authenticated-orcid":false,"given":"Shashikant","family":"Bagade","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy &amp; Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed\u2010to\u2010be University  Shirpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.115"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819985-5.00004-8"},{"key":"e_1_2_13_4_1","unstructured":"WHO. 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