{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:25:10Z","timestamp":1778703910651,"version":"3.51.4"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Nepeta rtanjensis<\/jats:italic>\n                    , a local endemic plant from Serbia, was processed using subcritical water extraction, and the resulting extract was further analyzed by high\u2010performance liquid chromatography\u2010diode array detection and gas chromatography\u2010mass spectrometry. Its biological activity, including antioxidant, anti\u2010inflammatory, antihyperglycemic, and antimicrobial effects, was evaluated in vitro. Rosmarinic acid (201.14\u00a0mg\/100\u00a0g extract), along with the monosaccharides glucose (16.15%) and fructose (10.41%), were the predominant metabolites. The extract exhibited significant antioxidant activities in 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (33.99 \u00b5mol TEAC\/100\u00a0g extract), 2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulphonic acid) (62.66 \u00b5mol TEAC\/100\u00a0g extract), and ferric ion reducing antioxidant power (311.55 \u00b5mol TEAC\/100\u00a0g extract) tests. Moderate anti\u2010inflammatory (half\u2010maximal inhibitory concentration [IC\n                    <jats:sub>50<\/jats:sub>\n                    ] = 80.72 \u00b5g\/mL) and antihyperglycemic (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 120.29 \u00b5g\/mL) effects were observed, although both were less potent than the respective standards. The extract showed strong activity, with inhibition zones of 25.00\u00a0mm against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and 18.00\u00a0mm against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . These results indicate that\n                    <jats:italic>N. rtanjensis<\/jats:italic>\n                    subcritical water extract is a promising candidate for use in antimicrobial formulations, particularly for topical applications or combating skin infections caused by resistant Gram\u2010positive bacteria, and highlight its potential in pharmaceutical and food preservation applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501737","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:29:50Z","timestamp":1759685390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unveiling the Chemical Composition and Bioactivity of\n                    <i>Nepeta rtanjensis<\/i>\n                    Subcritical Water Extract: A Potential Candidate for Pharmaceutical and Food Preservation Applications"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-1412","authenticated-orcid":false,"given":"Milica","family":"A\u0107imovi\u0107","sequence":"first","affiliation":[{"name":"Institute of Field and Vegetable Crops \u2013 National Institute of the Republic of Serbia  Novi Sad Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olja","family":"\u0160ovljanski","sequence":"additional","affiliation":[{"name":"Faculty of Technology University of Novi Sad  Novi Sad Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Vu\u010deti\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Technology University of Novi Sad  Novi Sad Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Ivanovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Technology and Metallurgy \u2013 National Institute of the Republic of Serbia 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