{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:57:43Z","timestamp":1785488263649,"version":"3.56.0"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Daphniphyllum neilgherrense<\/jats:italic>\n                    (Daphniphyllaceae), an ethnomedicinal plant, is used for skin diseases and various ailments, for which the studies on its anatomical, phytochemical and pharmacological properties are unexplored. Hence, the present study has been aimed to explore anatomical, phytochemical, antimicrobial, antioxidant, and anticancer activities. The anatomy of different parts of the plant is elaborated for the first time. Antibacterial activity observed (inhibition zone) against Gram\u2010positive bacteria (\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ) and Gram\u2010negative bacteria (\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ) was 18.10\u00a0\u00b1\u00a00.22 and 16.23\u00a0\u00b1\u00a00.15\u00a0mm, respectively, while the antifungal activity against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    was 17.41\u00a0\u00b1\u00a00.16\u00a0mm. Minimum inhibitory concentration of\n                    <jats:italic>D. neilgherrense<\/jats:italic>\n                    aqueous extract against tested bacterial species varied between 0.250 and 1.00\u00a0mg\/mL, while it was 2.00 and 4.00\u00a0mg\/mL for fungal species. Antioxidant potential (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) of\n                    <jats:italic>D. neilgherrense<\/jats:italic>\n                    was: 25.91\u00a0\u00b5g\/mL (DPPH); 80.17\u00a0\u00b5g\/mL (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ); reducing power assay OD value: 1.976. Cytotoxicity of the extract against MDA\u2010MB\u2010231 cell line revealed the IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 51.24\u00a0\u00b5g\/mL. The findings supported that phytochemicals, mainly flavonoids and phenols from\n                    <jats:italic>D. neilgherrense<\/jats:italic>\n                    leaf extract are highly responsible for pharmaceutical applications by demonstrating strong antioxidant, anticancer and broad\u2010spectrum antimicrobial activities.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501739","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:00:42Z","timestamp":1769191242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Morphoanatomical, Phytochemical, and Bioactive Insights Into the Ethnomedicinal Plant\n                    <i>Daphniphyllum neilgherrense<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1641-3785","authenticated-orcid":false,"given":"Venkatachalam","family":"Soundarya","sequence":"first","affiliation":[{"name":"PG and Research Department of Botany Government Arts College (Autonomous) Salem Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5951-1572","authenticated-orcid":false,"given":"Sugumar","family":"Mohanasundaram","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Crop Physiology SRM College of Agricultural Sciences, SRM Institute of Science and Technology Baburayanpettai, Maduranthagam Taluk, Chengalpattu District Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1101-6051","authenticated-orcid":false,"given":"Sundramurthy","family":"Venkatesa Prabhu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Engineering Karpagam Academy of Higher Education Coimbatore Tamil Nadu India"},{"name":"Centre for Natural Products and Functional Foods Karpagam Academy of Higher Education Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-8558","authenticated-orcid":false,"given":"Prakasham","family":"Radha","sequence":"additional","affiliation":[{"name":"Research Officer (Botany) Sci\u2010II &amp; Officer in\u2010Charge Siddha Medicinal Plants Garden (CCRS, Ministry of AYUSH, Government of India), India  Mettur Dam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7913-2027","authenticated-orcid":false,"given":"Murugan","family":"Gokul","sequence":"additional","affiliation":[{"name":"PG and Research Department of Botany Government Arts College (Autonomous) Salem Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7955-3593","authenticated-orcid":false,"given":"Natchimuthu","family":"Karmegam","sequence":"additional","affiliation":[{"name":"PG and Research Department of Botany Government Arts College (Autonomous) Salem Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.31838\/ijpr\/2021.13.01.487"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114143"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4172\/0974\u20108369.1000443"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2024.113336"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.55779\/nsb15411668"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117386"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203\u2010022\u201002844\u20107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117118"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.12980\/APJTB.4.2014C1107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117385"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.52711\/0974\u2010360X.2022.00350"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118966"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201003716\u20107"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2022.106555"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2022.106611"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116819"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202502821"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.56919\/usci.2432.011"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202502813"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2024.112147"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1305294"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c08314"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2024.103979"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0309795"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13399\u2010025\u201006553\u20101"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2022.102599"},{"issue":"2","key":"e_1_2_10_28_1","first-page":"13","article-title":"The Alkaloids: Genus Daphniphyllum (Daphniphyllaceae)","volume":"2","author":"Kothaiyal K.","year":"2011","journal-title":"International Research Journal of Pharmacy"},{"issue":"2","key":"e_1_2_10_29_1","first-page":"117","article-title":"Elucidation of Analgesic and Antipyretic Activities of Daphniphyllum neilgherrense (Wt.) 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