{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:57:12Z","timestamp":1792619832748,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100021114","name":"Dr. Babasaheb Ambedkar Marathwada University","doi-asserted-by":"publisher","award":["Plan&Stat\/RDC\/2022\u201023\/732\u201036"],"award-info":[{"award-number":["Plan&Stat\/RDC\/2022\u201023\/732\u201036"]}],"id":[{"id":"10.13039\/100021114","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study aims to develop novel antimalarial and antimicrobial agents by synthesizing a series of 25 triazolyl quinoline carboxylate derivatives via azide\u2013alkyne 1,3\u2010dipolar cycloaddition, starting from isatin and\n                    <jats:italic>p<\/jats:italic>\n                    \u2010fluoroacetophenone. Structural characterization was performed using IR,\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, and mass spectrometry. The synthesized hybrids were evaluated for their in vitro antimalarial activity against the chloroquine\u2010sensitive\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    3D7 strain. Among them, compounds\n                    <jats:bold>6e<\/jats:bold>\n                    ,\n                    <jats:bold>6h<\/jats:bold>\n                    , and\n                    <jats:bold>6i<\/jats:bold>\n                    exhibited notable potency, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 1.364 to 1.518\u00a0\u00b5M, underscoring their potential as promising antimalarial candidates. Furthermore, compounds\n                    <jats:bold>6g<\/jats:bold>\n                    ,\n                    <jats:bold>6h<\/jats:bold>\n                    ,\n                    <jats:bold>6m<\/jats:bold>\n                    , and\n                    <jats:bold>8a<\/jats:bold>\n                    demonstrated broad\u2010spectrum antimicrobial activity, while\n                    <jats:bold>6d<\/jats:bold>\n                    ,\n                    <jats:bold>6e<\/jats:bold>\n                    ,\n                    <jats:bold>6h<\/jats:bold>\n                    ,\n                    <jats:bold>8c<\/jats:bold>\n                    ,\n                    <jats:bold>8h<\/jats:bold>\n                    , and\n                    <jats:bold>8k<\/jats:bold>\n                    showed strong antioxidant potential through effective OH and DPPH radical scavenging. In silico ADME profiling using SwissADME and DeepPK revealed favorable pharmacokinetic properties and compliance with Lipinski's rule of five, suggesting good oral bioavailability. Density functional theory (DFT) calculations provided insights into the electronic structures, and molecular docking studies confirmed strong binding interactions with\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    falcipain\u20102 protease. Collectively, these findings highlight the therapeutic promise of this compound class as multifunctional agents targeting malaria and microbial infections.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501743","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T20:51:21Z","timestamp":1757105481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Design, Synthesis, and Evaluation of Triazolyl Quinoline Derivatives as Potential Antimalarial Agents"],"prefix":"10.1002","volume":"22","author":[{"given":"Amruta N.","family":"Bhagat","sequence":"first","affiliation":[{"name":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub Campus  Dharashiv India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajubai D.","family":"Bakale","sequence":"additional","affiliation":[{"name":"Terna Public Charitable Trust's College of Engineering  Dharashiv India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam V.","family":"Londhe","sequence":"additional","affiliation":[{"name":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub Campus  Dharashiv India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shriram B.","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub Campus  Dharashiv India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somesh S.","family":"Salunke","sequence":"additional","affiliation":[{"name":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub Campus  Dharashiv India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul A.","family":"More","sequence":"additional","affiliation":[{"name":"Department of Microbiology Dayanand Science College  Latur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avadhut P.","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Bharati Vidyapeeth College of Pharmacy  Kolhapur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prafulla B.","family":"Choudhari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Bharati Vidyapeeth College of Pharmacy  Kolhapur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravibhushan S.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub Campus  Dharashiv India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2526-8738","authenticated-orcid":false,"given":"Kishan P.","family":"Haval","sequence":"additional","affiliation":[{"name":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub Campus  Dharashiv India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201907224"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization World Malaria Report. (2023) https:\/\/www.who.int\/teams\/global\u2010malaria\u2010programme\/reports\/world\u2010malaria\u2010report\u20102023."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60024-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.02.024"},{"key":"e_1_2_8_6_1","volume-title":"Burger's Medicinal Chemistry and Drug Discovery","author":"Smithson D. C.","year":"2010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118493816.ch14"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22122268"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27031003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26735"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.134792"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17121632"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1424017"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557518666181018163448"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/09298673113209990170"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114959"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115973"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.202300212"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA03763J"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27030835"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2023.129551"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113865"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2024.129800"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.3628"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.11.082"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.10.009"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12321"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.01.032"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.10.015"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2011.01115.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201800728"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.11.022"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115694"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127434"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140072"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1740203"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00858"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.141594"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114247"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2023.2291826"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127579"},{"key":"e_1_2_8_42_1","unstructured":"Dassault Syst\u00e8mes BIOVIA Discovery Studio Visualizer. (2020)."},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2025.2511819"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-03495-6"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117565"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2269-7_19"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00104"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.81"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jchemed.0c00959"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2023.107826"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp990092i"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747519820932091"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c00597"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-3043-0"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00778"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2022.11.937"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202501743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202501743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202501743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:49:06Z","timestamp":1773488946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202501743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,5]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/cbdv.202501743"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202501743","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,5]]},"assertion":[{"value":"2025-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01743"}}