{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:59:47Z","timestamp":1788850787448,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The root of\n                    <jats:italic>Millettia speciosa<\/jats:italic>\n                    Champ has been traditionally and widely used for anti\u2010fatigue properties in folk culture. However, the active components and underlying mechanisms of\n                    <jats:italic>M. speciosa<\/jats:italic>\n                    \u2019s anti\u2010fatigue efficacy are still unclear. Notably, polysaccharides are considered the primary component for anti\u2010fatigue action in many traditional Chinese medicines. This study aimed to characterize the physicochemical properties of a polysaccharide\u2010rich fraction from\n                    <jats:italic>M. speciosa<\/jats:italic>\n                    (MSCP) and investigate its anti\u2010fatigue efficacy and underlying mechanisms. The results showed that MSCP was primarily composed of glucose, arabinose, and galactose in a ratio of 90.0:5.2:4.8 and contained two sugar\u2010peaks with molecular weights of 19\u00a0544 and 13\u00a0166\u00a0Da. The behavioral tests showed that MSCP could effectively extend the exhaustive swimming time and running time in the exercise\u2010induced fatigue model and combined stress\u2010induced fatigue model in mice. Treatment with MSCP reduced levels of blood urea nitrogen, blood lactic acid, lactate dehydrogenase, creatine kinase, and malondialdehyde, while increasing levels of muscle glycogen, hepatic glycogen, and superoxide dismutase. Furthermore, MSCP modulated the gut microbiota, which potentially contributes to its anti\u2010fatigue efficacy. Our research provides theoretical support for incorporating MSCP as a novel dietary supplement in functional foods designed to enhance anti\u2010fatigue properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501744","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T22:41:07Z","timestamp":1754001667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Physicochemical Properties and Anti\u2010Fatigue Efficacy of a Polysaccharide\u2010Rich Fraction Derived From\n                    <i>Millettia speciosa<\/i>\n                    Champ"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0948-6564","authenticated-orcid":false,"given":"Fu\u2010Yao","family":"Luo","sequence":"first","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai\u2010Ming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ma","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Fu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"},{"name":"Jining Medical University  Rizhao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"},{"name":"Changzhi Medical College  Changzhi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Jia","family":"Jin","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"},{"name":"Beijing Technology and Business University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Xue","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"},{"name":"North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-1508","authenticated-orcid":false,"given":"Chang\u2010Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xue","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.01.200"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.969827"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12163083"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117810"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2018.4294"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131440"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1004174"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4FO01108B"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5080843"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124611"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.766296"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131941"},{"issue":"9","key":"e_1_2_8_14_1","first-page":"293","article-title":"Botanical Characteristics, Chemical and Nutritional Composition and Pharmacological and Toxicological Effects of Medicinal and Edible Plant Millettia speciosa Champ","volume":"38","author":"Zhao Z. 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