{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:10:12Z","timestamp":1773493812707,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Lantana camara<\/jats:italic>\n                    (LC) L. is a widely distributed plant long used in African and Asian medicine for pain, inflammation, skin disorders, and cancer\u2010related symptoms. Young leaves are often brewed into teas to manage digestive and reproductive conditions, including ovarian inflammation. This study examined the methanol extract of young LC leaves for anti\u2010ovarian cancer and anti\u2010inflammatory potential through modulation of PI3K\/AKT\/mTOR and RAS\/RAF\/MEK\/ERK (MAPK) pathways. Phytochemical and gas chromatography\u2013mass spectrometry (GC\u2013MS) analyses identified over 30 bioactive compounds, notably oleic acid, pyrazine, and palmitic acid. Anticancer activity was tested on SKOV3 and OVCAR\u20103 ovarian cancer cells, with MTT assays showing strong cytotoxicity (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 12.6\u00a0\u00b1\u00a01.8 and 18.9\u00a0\u00b1\u00a02.1\u00a0\u00b5g\/mL), while sparing normal IOSE\u201080 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0&gt;\u00a0140\u00a0\u00b5g\/mL). Annexin V\u2010FITC\/PI staining indicated enhanced apoptosis, with early and late apoptotic populations reaching 31.4%\u00a0\u00b1\u00a02.5% and 24.7%\u00a0\u00b1\u00a03.1%. Western blot confirmed suppression of phosphorylated PI3K, AKT, mTOR, MEK, and ERK. In LPS\u2010stimulated RAW264.7 macrophages, the extract reduced nitric oxide, tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) (\u221243.2%), interleukin (IL)\u20106 (\u221239.8%), PGE2 (\u221247.6%), and cyclooxygenase\u20102 (COX\u20102) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). ELISA and immunofluorescence further validated cytokine inhibition. These results indicate that LC leaves possess strong anticancer and anti\u2010inflammatory properties, supporting their traditional use and therapeutic potential against ovarian cancer and inflammation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501758","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T20:46:43Z","timestamp":1761425203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Methanol Extract of Young\n                    <i>Lantana camara<\/i>\n                    L. Leaves Exhibit Anti\u2010Ovarian Cancer and Anti\u2010Inflammatory Effects via Inhibition of PI3K\/AKT\/mTOR and MAPK Pathways"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-4510","authenticated-orcid":false,"given":"Cletus Anes","family":"Ukwubile","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy University of Maiduguri  Maiduguri Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anietie Eyo","family":"Robert","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Alex Ekwueme Federal University Ndufu Alike Ikwo  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin Onyebuchi","family":"Ezema","sequence":"additional","affiliation":[{"name":"Biochemistry Unit Department of Science Laboratory Technology University of Nigeria  Nsukka Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan Braimah","family":"Yesufu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy University of Maiduguri  Maiduguri Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ademola Clement","family":"Famurewa","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Alex Ekwueme Federal University Ndufu Alike Ikwo  Abakaliki Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel Oise","family":"Ikpefan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Traditional Medicine Faculty of Pharmacy Delta State University  Abraka Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.145"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20109966\u201030\u201029"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2022.100396"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2024.100910"},{"key":"e_1_2_13_6_1","first-page":"d831","article-title":"A Review of Therapeutic Properties of Lantana camara","volume":"8","author":"Zeeshan M.","year":"2023","journal-title":"International Journal of Novel Research and Development"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.52403\/ijrr.20250173"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106882\u201013\u201033"},{"key":"e_1_2_13_9_1","first-page":"1828","article-title":"Anti\u2010Ovarian Cancer Potential of Phytocompound and Extract From South African Medicinal Plants and Their Role in the Development of Chemotherapeutic Agents","volume":"11","author":"Palanisamy C. P.","year":"2021","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010022\u201002584\u20104"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2020.07.001"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.20431\/2455-1538.1001002"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2022.07.001"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2024.103112"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.37446\/jet\/rsa\/3.1.2025.1-22"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2023.2292266"},{"key":"e_1_2_13_17_1","first-page":"279","article-title":"Acute and Subacute Toxicity Studies of Some Medicinal Plants","volume":"8","author":"Khalifa M. A.","year":"2022","journal-title":"Toxicology Reports"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.58349\/IJCIM.1.6.2024.00140"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2515690X241249534"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jchemed.2c00966"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000658\u20105"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534\u2010024\u201000637\u20107"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejbt.2018.12.005"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201011842\u20105"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0309795"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2021.100167"},{"key":"e_1_2_13_27_1","first-page":"614","article-title":"Isolation and Characterization of n\u2010Hexadecanoic Acid From Canthium parviflorum Leaves","volume":"8","author":"Krishnan K. 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