{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:29:18Z","timestamp":1791599358212,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Breast cancer continues to pose a significant global health burden, highlighting the urgent need for novel chemotherapeutic agents with improved selectivity and reduced toxicity. In this study, we rationally designed and synthesized six novel amide\u2010bridged triazole\u2010coumarin hybrids (\n                    <jats:bold>5a\u2013f<\/jats:bold>\n                    ) based on the known anticancer potential of both pharmacophores. The synthesized compounds were evaluated for their cytotoxicity in MCF\u20107 and MDA\u2500MB\u2500231 breast cancer cell lines and non\u2010tumorigenic MCF\u201010A cells. Among them, derivative\n                    <jats:bold>5f<\/jats:bold>\n                    showed the most potent anticancer activity with minimal toxicity toward normal cells. Mechanistic studies revealed that\n                    <jats:bold>5f<\/jats:bold>\n                    induced apoptosis by modulating Bax and Bcl\u25002 expression and arrested the cell cycle at the S phase via downregulation of CDK2 and Cyclin E. Molecular docking analyses confirmed its high binding affinity to CDK2 and Bcl\u25002, supporting its potential as a dual\u2010target inhibitor. These findings suggest that compound\n                    <jats:bold>5f<\/jats:bold>\n                    is a promising lead structure for the development of selective anticancer agents targeting breast cancer.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501775","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T20:49:06Z","timestamp":1757105346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Design, Synthesis, and Molecular Docking of Triazole\u2010Coumarin Hybrids as Potent Breast Cancer Inhibitors Targeting Cell Cycle and Apoptosis"],"prefix":"10.1002","volume":"22","author":[{"given":"Murat","family":"Keser","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Izmir Tepecik Education and Research Hospital University of Health Sciences  Izmir 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