{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T11:09:16Z","timestamp":1787483356776,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to optimize microwave\u2010assisted extraction of phenolic compounds from the undervalued traditional plant\n                    <jats:italic>Euphorbia guyoniana<\/jats:italic>\n                    (Boiss. &amp; Reut.) using the central composite design of response surface methodology. The independent variables were extraction time, ethanol concentration in the extractive solvent, microwave power, and feed\u2010to\u2010solvent ratio while the dependent variables were total phenolic content (TPC) and total flavonoid content (TFC). Extract obtained by using the optimal extraction parameters was evaluated for its in vivo anti\u2010inflammatory activity by the carrageenan\u2010induced paw edema model and was subjected to RP\u2013HPLC\u2013PDA\u2013ESI\u2013MS analysis to investigate the presence of phenolic compounds. The optimal conditions for highest TPC (377.22\u00a0\u00b1\u00a05.42\u00a0mg GAE\/g) and TFC (184.40\u00a0\u00b1\u00a01.18\u00a0mg QE\/g) were obtained at an extraction time of 25\u00a0min, an ethanol concentration of 40.57%, a microwave power of 450\u00a0W and a feed\u2010to\u2010solvent ratio of 1:17.5. Optimal extract of\n                    <jats:italic>E. guyoniana<\/jats:italic>\n                    significantly higher inhibited carrageenan\u2010induced inflammation with a concentration of 50\u00a0mg\/kg (79.37%) when compared with the reference anti\u2010inflammatory drug ibuprofen (43.06%). Finally, above the previously reported phenolic constituents, that is, quercetin and kaempferol derivatives, hydroxycinnamates have been identified for the first time in\n                    <jats:italic>E. guyoniana<\/jats:italic>\n                    plant extract.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501804","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T19:10:26Z","timestamp":1759000226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Green Microwave\u2010Assisted Extraction of\n                    <i>Euphorbia guyoniana<\/i>\n                    : Optimization, Metabolite Profile, and In Vivo Anti\u2010Inflammatory Potential"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-3183","authenticated-orcid":false,"given":"Halima Meriem","family":"Issaadi","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry University of Sciences and Technology Houari Boumediene (USTHB)  Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacine","family":"Nait Bachir","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Natural and Life Sciences University Saad Dahlab\u2013Blida 1  Blida Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaeddine","family":"Ben Naama","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry University of Sciences and Technology Houari Boumediene (USTHB)  Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad","family":"Aiter","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry University of Sciences and Technology Houari Boumediene (USTHB)  Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korn\u00e9l","family":"Sz\u0151ri","sequence":"additional","affiliation":[{"name":"Institute of Pharmacognosy University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Hunyadi","sequence":"additional","affiliation":[{"name":"Institute of Pharmacognosy University of Szeged  Szeged Hungary"},{"name":"Interdisciplinary Centre for Natural Products University of Szeged  Szeged Hungary"},{"name":"HUN\u2010REN\u2010SZTE Biologically Active Natural Products Research Group  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Nouvelle Flore De l'Alg\u00e9rie et Des R\u00e9gions D\u00e9sertiques m\u00e9ridionales","author":"Quezel P.","year":"1963"},{"key":"e_1_2_9_3_1","volume-title":"Catalogue Des Plantes Spontan\u00e9es Du Sahara Septentrional Alg\u00e9rien","author":"Chehma A.","year":"2019"},{"key":"e_1_2_9_4_1","volume-title":"Atlas Floristique De Lavall\u00e9e De L'Oued Righ Par \u00c9cosyst\u00e8me","author":"Kherraze M. 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