{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:36:09Z","timestamp":1791236169262,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574687"],"award-info":[{"award-number":["82574687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Artemisia vestita<\/jats:italic>\n                    is a traditional Tibetan folk medicine. Bioactivity\u2010guided fractionation revealed that the petroleum ether fraction of\n                    <jats:italic>A. vestita<\/jats:italic>\n                    possessed potent anti\u2010complementary activity (CH\n                    <jats:sub>50<\/jats:sub>\n                    : 0.016 \u00b1 0.006\u00a0mg\/mL), demonstrating therapeutic efficacy against H1N1\u2010induced viral pneumonia in murine models. Subsequent phytochemical analysis of this bioactive extract using silica gel chromatography coupled with semi\u2010preparative high\u2010performance liquid chromatography yielded 14 compounds, including three new monoterpenes (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>3<\/jats:bold>\n                    ) and one coumarin (\n                    <jats:bold>13<\/jats:bold>\n                    ) with relatively high abundance. Notably, studies on the activity of the isolated compounds revealed that the coumarin (scopoletin) exhibits dominant anti\u2010complementary activity and provides significant protective effects against H1N1\u2010induced viral pneumonia in mice. This study provides insights into the development and utilization of\n                    <jats:italic>A. vestita<\/jats:italic>\n                    and scopoletin.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501817","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:57:08Z","timestamp":1767869828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010Complementary Constituents From\n                    <i>Artemisia vestita<\/i>\n                    Alleviate H1N1\u2010Induced Acute Lung Injury"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5396-7853","authenticated-orcid":false,"given":"Xue","family":"Liao","sequence":"first","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Department of Natural Medicine, School of Pharmacy Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Bin","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Natural Medicine, School of Pharmacy Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai\u2010Chang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Natural Medicine, School of Pharmacy Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Deji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Feng","family":"Xiu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9420-7090","authenticated-orcid":false,"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Natural Medicine, School of Pharmacy Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00186214"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2020.1800726"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010021\u201000737\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106710"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.10.027"},{"key":"e_1_2_10_7_1","first-page":"14","article-title":"Clinical Efficacy of Tibetan Medicine Wuwei Ganlu SAN in Treatment of Rheumatoid Arthritis","volume":"29","author":"Sai R. 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