{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:13:10Z","timestamp":1773493990551,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Considerable evidence suggests that metal ions play crucial roles in Alzheimer's disease (AD) progression, spurring the development of metal\u2010involved therapeutic strategies. In this study, biochanin A, a bioactive ingredient derived from\n                    <jats:italic>Trifolium pratense L<\/jats:italic>\n                    . (a traditional Chinese medicine [TCM]), was identified as a lead compound for the rational design of multifunctional metal chelators. A series of biochanin A derivatives (compounds\n                    <jats:bold>a\u2013e<\/jats:bold>\n                    ) was synthesized through a one\u2010step carbamate introduction reaction. Their drug\u2010likeness and pharmacokinetic profiles were assessed using an online prediction server. The bioactivities, including metal ion chelation, \u03b2\u2010amyloid aggregation regulation, reactive oxygen species elimination, cholinesterase inhibition, and neurocytotoxicity were evaluated. The results indicated that compounds (\n                    <jats:bold>a\u2013e<\/jats:bold>\n                    ) possessed favorable pharmacokinetic profiles and potential as multifunctional metal chelators with minimal neurocytotoxicity, with compound\n                    <jats:bold>d<\/jats:bold>\n                    emerging as a particularly promising candidate. These findings may provide meaningful information for developing novel multifunctional metal chelators for AD treatment and innovative drugs derived from TCM.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501827","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:55:46Z","timestamp":1761155746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Biochanin A Carbamate Derivatives as Multifunctional Anti\u2010Alzheimer's Disease Metal Chelators: Design, Synthesis, and Activity Evaluation"],"prefix":"10.1002","volume":"22","author":[{"given":"Yiyi","family":"Sun","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjie","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia 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