{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:46:40Z","timestamp":1792464400590,"version":"4.5.0"},"reference-count":68,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, several choline chloride (ChCl)\u2010based deep eutectic solvent (DES) combinations were prepared at different molar ratios (1\/1, 1\/2, and 2\/1) using amine (urea), polyols (ethylene glycol and glycerol), and carboxylic acids (lactic acid, formic acid, propionic acid, and acetic acid). The performances of the DESs in the homogeniser\u2010assisted extraction of\n                    <jats:italic>Prunus spinosa<\/jats:italic>\n                    L. fresh fruit were compared depending on the total phenolic content (TPC), total anthocyanin content (TAC), and 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl free radical scavenging activity (antioxidant activity [AA]) yields. Based on the findings of Tukey's test for multiple comparisons, ChCl\/formic acid (2\/1) provided the best extraction efficiency with statistically significant differences (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Fourier\u2010transform infrared spectroscopy was used to confirm the formation of the proposed DES. Furthermore, the proposed DES also showed better performance compared to conventional aqueous ethanol (60%, v\/v) and water. Then, the selected DES (ChCl\/formic acid, 2\/1) was employed for the optimization study using the Box\u2010Behnken Design of the response surface methodology. The optimum process conditions for the maximum yields of TPC (52.34\u00a0mg\u2010GAE\/g\u2010FF), TAC (2.09\u00a0mg\u2010cyn\u20103\u2010glu\/g\u2010FF), and AA (89.21%) were found to be 50% (v\/v) water in the DES, 0.833\u00a0g of material, and 69.906\u00a0s extraction time.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501858","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:44:40Z","timestamp":1755798280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tailoring Natural Solvents: Deep Eutectic Approach for Recovering Bioactives From\n                    <i>Prunus spinosa<\/i>\n                    L."],"prefix":"10.1002","volume":"22","author":[{"given":"Rabia Nur","family":"Bozkurt","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering and Natural Sciences Istanbul Health and Technology University  Beyoglu T\u00fcrkiye"},{"name":"Department of Chemical Engineering, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa  Avc\u0131lar T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seid Reza","family":"Falsafi","sequence":"additional","affiliation":[{"name":"Food Science and Technology Division, Agricultural Engineering Research Department Safiabad Agricultural and Natural Resources Research and Education Center (AREEO)  Dezful Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-9823","authenticated-orcid":false,"given":"Selin","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa  Avc\u0131lar 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