{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:02:02Z","timestamp":1775890922389,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Antibiotic\u2010resistant bacterial pathogens represent a critical global health challenge, largely due to their ability to form biofilms\u2014structured microbial communities that protect bacteria from external threats and contribute to persistent, chronic infections. In this study, we evaluated the antibiofilm potential of tosylated molecules synthesized from propargyl alcohol and polyethylene glycol against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    H103. Among the tested compounds, propargyl tosylate demonstrated potent antibiofilm activity by effectively disrupting both the formation and maintenance of biofilms. Notably, this activity was achieved without exhibiting direct antibacterial effects, indicating that the compound interferes with specific stages of biofilm development rather than bacterial viability. In contrast,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    biofilms remained unaffected, suggesting a potential selectivity of the compound toward Gram\u2010negative bacteria. Structure\u2013activity relationship analysis underlined the crucial role of the benzenesulfonate (tosyl) moiety in enhancing antibiofilm properties. These findings suggest that propargyl tosylate is a promising lead compound for the development of non\u2010bactericidal agents specifically targeting\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    biofilms, offering a novel approach in the fight against biofilm\u2010associated infections.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501881","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T10:06:08Z","timestamp":1765188368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Evaluation of Novel Tosylated Compounds as Selective Antibiofilm Agents against\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-8249","authenticated-orcid":false,"given":"Sarra","family":"Zouaoui","sequence":"first","affiliation":[{"name":"Applied Organic Synthesis Laboratory, Faculty of Exact and Applied Sciences University Oran1 Ahmed Benbella  Oran Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magalie","family":"Barreau","sequence":"additional","affiliation":[{"name":"University of Rouen Normandy, University of Caen Normandy, Normandie Univ, CBSA UR 4312  Rouen France"},{"name":"University of Rouen Normandy, Evreux Health Safety Platform (PS2E)  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miloud Mohamed","family":"Mazari","sequence":"additional","affiliation":[{"name":"Applied Organic Synthesis Laboratory, Faculty of Exact and Applied Sciences University Oran1 Ahmed Benbella  Oran Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Lesouhaitier","sequence":"additional","affiliation":[{"name":"University of Rouen Normandy, University of Caen Normandy, Normandie Univ, CBSA UR 4312  Rouen France"},{"name":"University of Rouen Normandy, Evreux Health Safety Platform (PS2E)  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Vieillard","sequence":"additional","affiliation":[{"name":"University of Rouen Normandy, Evreux Health Safety Platform (PS2E)  Rouen France"},{"name":"Universit\u00e9 de Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour El Houda","family":"Nourai","sequence":"additional","affiliation":[{"name":"Applied Organic Synthesis Laboratory, Faculty of Exact and Applied Sciences University Oran1 Ahmed Benbella  Oran Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serine","family":"Madji","sequence":"additional","affiliation":[{"name":"Laboratory of Transfer Phenomena Faculty of Mechanical and Process Engineering (USTHB)  El\u2010Alia Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nourredine","family":"Karkachi","sequence":"additional","affiliation":[{"name":"Department of Biology, Applied Microbiology Laboratory University Oran1 Ahmed Benbella  Oran Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Adjdir","sequence":"additional","affiliation":[{"name":"Applied Organic Synthesis Laboratory, Faculty of Exact and Applied Sciences University Oran1 Ahmed Benbella  Oran Algeria"},{"name":"Laboratory of Elaboration and Spectroscopic Characterizations of Structural and Electronic Properties of Materials, Faculty of Technology University of Sa\u00efda Dr. Tahar Moulay  Saida Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01822\u201025"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/533452"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2475067"},{"key":"e_1_2_11_5_1","unstructured":"World Health Organization.Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report.2022 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