{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:37:43Z","timestamp":1790314663418,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>Euphorbia greenwayi<\/jats:italic>\n                    essential oil (EGEO) was analyzed by GC\u2013MS, and 17 components were identified, accounting for 99.70%, predominantly monoterpene (98.28%). The major components were limonene (26.46%), \u03b1\u2010pinene (18.50%), 1,8\u2010cineole (25.62%), \u03b2\u2010pinene (6.52%), and \u03b3\u2010terpinene (4.36%). Antioxidant potential was evaluated using DPPH and ABTS radical scavenging assays. The EGEO exhibited dose\u2010dependent activity, with respective IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 417.7 and 448.8\u00a0mg\/L, indicating moderate antioxidant capacity. Cytotoxic activity was assessed on THLE\u20102 (normal liver), MCF\u20107 (breast cancer), and HepG2 (liver cancer) cells. The EGEO exhibited negligible cytotoxicity toward THLE\u20102 cells (&gt;\u00a093% viability at 0.1\u2013500\u00a0\u00b5g\/mL), while showing pronounced cytotoxicity against MCF\u20107 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0166.65\u00a0\u00b5g\/mL) and moderate activity against HepG2 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0328.03\u00a0\u00b5g\/mL), highlighting selective antiproliferative effects. Molecular docking further substantiated the anticancer potential of EO constituents. Limonene demonstrated the strongest binding affinity against aurora kinase A (\u221210.586\u00a0kcal\/mol) and the tumor suppressor PTEN (\u22126.397\u00a0kcal\/mol), outperforming other tested monoterpenes. It established key interactions with hinge (Ala273), DFG motif residues in aurora A, and P\u2010loop residues (Cys124, Arg130) in PTEN, positioning it as a dual\u2010target lead compound. Sabinene also showed favorable binding to aurora A (\u22129.964\u00a0kcal\/mol) but was less active toward PTEN. These findings suggested that EGEO possesses promising antioxidant and anticancer properties, with limonene emerging as a potential multitarget therapeutic agent for oxidative stress\u2010related and proliferative disorders.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501894","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:20:00Z","timestamp":1770884400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multitarget Antioxidant and Anticancer Potential of\n                    <i>Euphorbia greenwayi<\/i>\n                    Essential Oil: Phytochemical Profiling and Molecular Insights"],"prefix":"10.1002","volume":"23","author":[{"given":"Ahmed F.","family":"Essa","sequence":"first","affiliation":[{"name":"Department of Natural Compounds Chemistry National Research Centre, Dokki  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania F.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Natural Compounds Chemistry National Research Centre, Dokki  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab A.","family":"El\u2010Gendy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Medical Research and Clinical Studies Institute National Research Centre, Dokki  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninh The","family":"Son","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Vietnam Academy of Science and Technology, Nghia Do Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Pham","family":"The","sequence":"additional","affiliation":[{"name":"University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, Nghia Do Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd El\u2010Nasser G. El","family":"Gendy","sequence":"additional","affiliation":[{"name":"Medicinal and Aromatic Plants Research Department National Research Centre, Dokki  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Abd\u2010ElGawad","sequence":"additional","affiliation":[{"name":"Department of Botany, Faculty of Science Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kasai","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Tokushima Bunri University  Yamashiro\u2010cho Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Imagawa","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Tokushima Bunri University  Yamashiro\u2010cho Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-3623","authenticated-orcid":false,"given":"Abdelsamed 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