{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:15:08Z","timestamp":1778901308665,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Montanoa tomentosa<\/jats:italic>\n                    has been used in Mexican traditional medicine as a labor inducer and contraceptive, as well as for the treatment of pain after childbirth. In this sense,\n                    <jats:italic>M. tomentosa<\/jats:italic>\n                    is an important source of metabolites with potent anti\u2010inflammatory activity. The objective of this work was to evaluate the anti\u2010inflammatory activity of extracts:\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane (\n                    <jats:bold>MtHex<\/jats:bold>\n                    ), ethyl acetate (\n                    <jats:bold>MtAc<\/jats:bold>\n                    ), and methanol (\n                    <jats:bold>MtMe<\/jats:bold>\n                    ), and compounds isolated from leaves of\n                    <jats:italic>M. tomentosa<\/jats:italic>\n                    . The anti\u2010inflammatory effect was evaluated in the 12\u2010O\u2010tetradecanoylphorbol\u201013\u2010acetate (TPA)\u2010induced ear edema model in mice. The compounds were structurally characterized using one\u2010 and two\u2010dimensional nuclear magnetic resonance spectroscopy. The\n                    <jats:bold>MtHex<\/jats:bold>\n                    (1\u00a0mg\/ear) reduced edema (61.16 \u00b1 3.8%), showing a similar effect to indomethacin (70.02 \u00b1 1.24%). From the\n                    <jats:bold>MtHex<\/jats:bold>\n                    extract, the following compounds were isolated and identified:\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010sitosterol (\n                    <jats:bold>1<\/jats:bold>\n                    ), stigmasterol (\n                    <jats:bold>2<\/jats:bold>\n                    ), kaurenoic acid (\n                    <jats:bold>3<\/jats:bold>\n                    ), grandiflorenic acid (\n                    <jats:bold>4<\/jats:bold>\n                    ), taraxasterol (\n                    <jats:bold>5<\/jats:bold>\n                    ), and 15\u2010cinnamoylkaurenic acid (\n                    <jats:bold>6<\/jats:bold>\n                    ). Compounds\n                    <jats:bold>5<\/jats:bold>\n                    ,\n                    <jats:bold>6<\/jats:bold>\n                    , and the mixture of\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    were evaluated; compound\n                    <jats:bold>6<\/jats:bold>\n                    showed the most significant effect in the TPA model (79.05 \u00b1 3.07%). These exploratory results demonstrate that\n                    <jats:italic>M. tomentosa<\/jats:italic>\n                    could be an important source of terpene\u2010type metabolites such as kaurenoic acid derivatives and sterols with potential anti\u2010inflammatory effects.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501896","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T03:56:08Z","timestamp":1760414168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Terpenoid Compounds From\n                    <i>Montanoa tomentosa<\/i>\n                    Cerv. With Anti\u2010inflammatory Potential"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2447-7036","authenticated-orcid":false,"given":"Eric Jaziel","family":"Medrano\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas Universidad Ju\u00e1rez Aut\u00f3noma De Tabasco  Cunduacan Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6712-6765","authenticated-orcid":false,"given":"Ammy Joana","family":"Gallegos\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n De Ciencias B\u00e1sicas e Ingenier\u00eda Universidad Popular de La Chontalpa  Cardenas Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-8584","authenticated-orcid":false,"given":"Ricardo","family":"L\u00f3pez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas Universidad Ju\u00e1rez Aut\u00f3noma De Tabasco  Cunduacan Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-3933","authenticated-orcid":false,"given":"Patricia","family":"\u00c1lvarez\u2010Fitz","sequence":"additional","affiliation":[{"name":"Investigadoras e Investigadores por M\u00e9xico Universidad Aut\u00f3noma de Guerrero  Chilpancingo Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1670","authenticated-orcid":false,"given":"Manas\u00e9s","family":"Gonz\u00e1lez\u2010Cortazar","sequence":"additional","affiliation":[{"name":"Centro De Investigaci\u00f3n Biom\u00e9dica Del Sur Instituto Mexicano del Seguro Social  Xochitepec Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9056-3568","authenticated-orcid":false,"given":"Maribel","family":"Herrera\u2010Ru\u00edz","sequence":"additional","affiliation":[{"name":"Centro De Investigaci\u00f3n Biom\u00e9dica Del Sur Instituto Mexicano del Seguro Social  Xochitepec Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-5958","authenticated-orcid":false,"given":"Alejandro","family":"Zamilpa","sequence":"additional","affiliation":[{"name":"Centro De Investigaci\u00f3n Biom\u00e9dica Del Sur Instituto Mexicano del Seguro Social  Xochitepec Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3734-7780","authenticated-orcid":false,"given":"Carlos Ernesto","family":"Lobato\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas Universidad Ju\u00e1rez Aut\u00f3noma De Tabasco  Cunduacan Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1522-0384","authenticated-orcid":false,"given":"Cristian Octavio","family":"Barredo\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas Universidad Ju\u00e1rez Aut\u00f3noma De Tabasco  Cunduacan Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7528-4082","authenticated-orcid":false,"given":"Abraham","family":"G\u00f3mez\u2010Rivera","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas Universidad Ju\u00e1rez Aut\u00f3noma De Tabasco  Cunduacan Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"F.Xim\u00e9nez Quatro libros de la naturaleza y virtudes de las plantas y animales que est\u00e1n recevidos en el uso de medicina en la Nueva Espa\u00f1a y la m\u00e9todo y correcci\u00f3n y preperaci\u00f3n que para administrarlas se requiere con lo que el doctor Francisco Hern\u00e1ndez escrivio en lengua latina(Viuda de Diego L\u00f3pez Davalos 1615)."},{"issue":"7","key":"e_1_2_10_3_1","first-page":"493","article-title":"Uso y conocimiento de plantas medicinales por hombres y mujeres en dos localidades ind\u00edgenas en Coyomeapan, Puebla, M\u00e9xico","volume":"36","author":"Vazquez M. B.","year":"2011","journal-title":"Internciencia"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(84)90098-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jplph.2009.06.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(83)90003-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.12.070"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.158"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(87)80005-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf030672j"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/scipharm92010009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955706777934937"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.03.033"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2004.03.008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-011-0321-x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.02.018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.09.056"},{"issue":"43","key":"e_1_2_10_18_1","first-page":"285","article-title":"Anti\u2010Inflammatory Activity of Critonia aromatisans and Montanoa grandiflora Leaves Extracts, Plants Used in Mayan Traditional Medicine to Treat Inflammation","author":"Villa\u2010De La Torre F.","year":"2017","journal-title":"Polibot\u00e1nica"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01573-1"},{"issue":"1","key":"e_1_2_10_20_1","first-page":"88","article-title":"Isolation and Characterization of Stigmasterol and \u03b2\u2010Sitosterol From Odontonema strictum (Acanthaceae)","volume":"2","author":"Pierre L. L.","year":"2015","journal-title":"Journal of Innovations in Pharmaceutical and Biological Sciences"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(90)85139-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1139\/v84-416"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)87309-9"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(82)85198-4"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)88742-7"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650070213"},{"issue":"4","key":"e_1_2_10_27_1","first-page":"303","article-title":"The Biological Activity of Naturally Occurring Kaurene Diterpenes","volume":"68","author":"Ghisalberti E. L.","year":"1997","journal-title":"Fitoterapia"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-015-0559-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000227584"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.21010\/ajtcam.v14i1.6"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(83)90005-7"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199702)11:1<11::AID-PTR936>3.0.CO;2-V"},{"key":"e_1_2_10_33_1","unstructured":"NOM\u2010062\u2010ZOO\u20101999 Especificaciones T\u00e9cnicas para la Producci\u00f3n Cuidado y Uso de los Animales de Laboratorio.DirectorateGeneral of Standards:Mexico City Mexico 1999. Available online: https:\/\/www.gob.mx\/cms\/uploads\/attachment\/file\/203498\/NOM\u2010062ZOO\u20101999_220801.pdf(accessed on 12 October 2024)."},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11060794"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202501896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202501896","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202501896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:50:37Z","timestamp":1773489037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202501896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/cbdv.202501896"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202501896","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]},"assertion":[{"value":"2025-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01896"}}