{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:15:02Z","timestamp":1783368902140,"version":"3.54.6"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Plant\u2010derived foods are rich in bioactive compounds with notable therapeutic potential. Plantain (\n                    <jats:italic>Musa paradisiaca<\/jats:italic>\n                    L.) is widely cultivated and traditionally used in managing inflammation and diabetes. This study investigated the cardioprotective effects of the ethanol extract of a polyphenol\u2010rich unripe (green)\n                    <jats:italic>M. paradisiaca<\/jats:italic>\n                    peel in a rat model of type 2 diabetes. Bioactive compounds were identified using GC\u2010FID, followed by molecular docking with relevant protein targets. Type 2 diabetes was induced using a high\u2010fat diet (12 weeks) and streptozotocin (35\u00a0mg\/kg). Diabetic rats were treated with 200 and 400\u00a0mg\/kg extract for 30 days. HFD\/STZ\u2010induced diabetic rats showed elevated fasting blood and serum glucose, dyslipidemia, increased creatine kinase\u2010MB, lactate dehydrogenase, interleukin\u20106, C\u2010reactive protein, tumor necrosis factor\u2010\u03b1, and troponin I, all significantly reduced by the extract. Reduced adiponectin levels were significantly improved (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05), alongside the attenuation of oxidative stress. Histology revealed reduced myocyte degeneration and inflammatory cell infiltration with evidence of regeneration. Molecular docking suggested that polyphenols contributed to the observed antidiabetic activity. In conclusion, the ethanol extract of green plantain peels possesses antihyperglycemic, antidyslipidemic, anti\u2010inflammatory, antioxidant, and cardioprotective properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501897","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:46:02Z","timestamp":1781847962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unripe\n                    <i>Musa paradisiaca<\/i>\n                    Peel Extract Improves Dyslipidemia and Cardiac Dysfunction in High\u2010Fat Diet\/Streptozotocin\u2010Induced Type 2 Diabetic Rats"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-1235","authenticated-orcid":false,"given":"Mary Tolulope","family":"Olaleye","sequence":"first","affiliation":[{"name":"Biochemical and Molecular Pharmacology and Toxicology Laboratories Department of Biochemistry Federal University of Technology  Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2561-1903","authenticated-orcid":false,"given":"Titilope Ruth","family":"Komolafe","sequence":"additional","affiliation":[{"name":"Biochemical and Molecular Pharmacology and Toxicology Laboratories Department of Biochemistry Federal University of Technology  Akure Nigeria"},{"name":"Department of Biology Jackson State University  Jackson USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9611-2784","authenticated-orcid":false,"given":"Taiwo Alex","family":"Olowookere","sequence":"additional","affiliation":[{"name":"Biochemical and Molecular Pharmacology and Toxicology Laboratories Department of Biochemistry Federal University of Technology  Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1165-5961","authenticated-orcid":false,"given":"Temitope Blessing","family":"Awoyinka","sequence":"additional","affiliation":[{"name":"Biochemical and Molecular Pharmacology and Toxicology Laboratories Department of Biochemistry Federal University of Technology  Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatoyin Comfort","family":"Banji","sequence":"additional","affiliation":[{"name":"Biochemical and Molecular Pharmacology and Toxicology Laboratories Department of Biochemistry Federal University of Technology  Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-4185","authenticated-orcid":false,"given":"Oluwamodupe Mary","family":"Abayomi","sequence":"additional","affiliation":[{"name":"Biochemical and Molecular Pharmacology and Toxicology Laboratories Department of Biochemistry Federal University of Technology  Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-5863","authenticated-orcid":false,"given":"Kayode","family":"Komolafe","sequence":"additional","affiliation":[{"name":"Department of Biology Jackson State University  Jackson USA"},{"name":"Department of Biochemistry, Faculty of Science Federal University Oye\u2010Ekiti  Ekiti Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1969-1967","authenticated-orcid":false,"given":"Afolabi Akintunde","family":"Akindahunsi","sequence":"additional","affiliation":[{"name":"Biochemical and Molecular Pharmacology and Toxicology Laboratories Department of Biochemistry Federal University of Technology  Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afolabi Clement","family":"Akinmoladun","sequence":"additional","affiliation":[{"name":"Biochemical and Molecular Pharmacology and Toxicology Laboratories Department of Biochemistry Federal University of Technology  Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147644"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05319-w"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176275"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12791"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.83692"},{"key":"e_1_2_9_7_1","first-page":"1","article-title":"Meta\u2010Analysis Flavonoids From Traditional Chinese Herbs for Diabetes in Rats: A Network Meta\u2010Analysi","volume":"42","author":"Wu Y.","year":"2022","journal-title":"Journal of Traditional Chinese 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