{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:59:58Z","timestamp":1775890798951,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of oxazole\u2010pyrimidine\u2010isoquinoline amides\n                    <jats:bold>11a\u2013j<\/jats:bold>\n                    is prepared, and their chemical structures were characterized by analogy and spectral data (\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010NMR, and mass spectrometry). Further, all analogues were assessed against four human cancer cell lines, such as human breast cancer (MCF\u20107), human lung cancer (A549), human colon cancer (Colo\u2010205), and human ovarian cancer (A2780) by employing the MTT method. The results found that maximum compounds exhibited good to judicious anticancer activities. Those results were compared with the known chemotherapeutic agent Etoposide. Among all, four compounds\n                    <jats:bold>11a<\/jats:bold>\n                    ,\n                    <jats:bold>11b<\/jats:bold>\n                    ,\n                    <jats:bold>11c<\/jats:bold>\n                    , and\n                    <jats:bold>11d<\/jats:bold>\n                    displayed remarkable activity than Etoposide. All compounds showed selective cytotoxicity against cancer cells but not against normal Vero cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    = &gt;24\u00a0\u00b5M), justifying the designing approach to develop a selective anticancer agent. Subsequently, compound\n                    <jats:bold>11a<\/jats:bold>\n                    was scrutinized using molecular docking experiments, which evaluate the binding interaction of\n                    <jats:bold>11a<\/jats:bold>\n                    with topoisomerase enzyme (RSCBPDB: 4gfh) and demonstrated the highest anti\u2010cancer activity than Etoposide.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501905","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T20:08:45Z","timestamp":1764792525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery and Evaluation of Oxazole\u2010Pyrimidine\u2010Isoquinoline Amides as Anticancer Leads"],"prefix":"10.1002","volume":"23","author":[{"given":"Divya","family":"Komirishetti","sequence":"first","affiliation":[{"name":"Department of Chemistry Mahatma Gandhi University  Nalgonda India"},{"name":"Telangana Social Welfare Residential Degree College for Women  Nalgonda India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramchander","family":"Merugu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Mahatma Gandhi University  Nalgonda India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasam","family":"Savitha","sequence":"additional","affiliation":[{"name":"Telangana Social Welfare Residential Degree College for Women  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0029-7815","authenticated-orcid":false,"given":"Vasantha","family":"Mittapelli","sequence":"additional","affiliation":[{"name":"Department of Chemistry Mahatma Gandhi University  Nalgonda 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