{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:00:01Z","timestamp":1775890801402,"version":"3.50.1"},"reference-count":98,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Amazonian plant species possess a vast potential for antimicrobial action and are the subject of research due to their rich biodiversity and varied bioactive compounds. Among these,\n                    <jats:italic>Paullinia cupana<\/jats:italic>\n                    ,\n                    <jats:italic>Bertholletia excelsa<\/jats:italic>\n                    , and\n                    <jats:italic>Dinizia excelsa<\/jats:italic>\n                    stand out. These species are notable for their great ecological, commercial, and economic value in Brazil. This work aims to compile and review scientific studies that provide a comprehensive and updated overview of the antimicrobial potential of three Amazonian plant species.\n                    <jats:italic>P. cupana<\/jats:italic>\n                    is effective against 21 bacterial species, and 81% of guarana seed extracts showed bactericidal activity.\n                    <jats:italic>B. excelsa<\/jats:italic>\n                    is active against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    sp., and\n                    <jats:italic>Candida<\/jats:italic>\n                    sp., whereas\n                    <jats:italic>D. excelsa<\/jats:italic>\n                    demonstrates activity against\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    . Continuing to investigate the antimicrobial potential of Amazonian species can lead to the development of new drugs effective against resistant pathogens, promoting the conservation and sustainable use of the forest and demonstrating the economic and medicinal value of native plants.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501911","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T10:11:38Z","timestamp":1765188698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antimicrobial Potential of Three Native Plant Species From the Brazilian Amazon: A Review"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8628-5793","authenticated-orcid":false,"given":"Natalia Oliveira Totti","family":"de Lara","sequence":"first","affiliation":[{"name":"Faculdade Galileu (GALILEU)  Botucatu S\u00e3o Paulo Brazil"},{"name":"Department of Biotechnology, Genetics and Cell Biology State University of Maring\u00e1 (UEM) Maring\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5451-4320","authenticated-orcid":false,"given":"Julio Cesar","family":"Polonio","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Genetics and Cell Biology State University of Maring\u00e1 (UEM) Maring\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5632-929X","authenticated-orcid":false,"given":"Halison Correia","family":"Golias","sequence":"additional","affiliation":[{"name":"Department of Humanities Microbiology Laboratory Federal Technological University of Paran\u00e1 (UTFPR)  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1146961"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003629\u20106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/conservation5030035"},{"key":"e_1_2_11_5_1","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica [IBGE].Censo Demogr\u00e1fico 2022(IBGE 2022) https:\/\/censo2022.ibge.gov.br."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18326"},{"key":"e_1_2_11_7_1","unstructured":"A.Alencar R.Silvestrini J.Gomes andG.Savian Amaz\u00f4nia em chamas: O novo e alarmante patamar do desmatamento na Amaz\u00f4nia(IPAM Amaz\u00f4nia 2022)."},{"key":"e_1_2_11_8_1","unstructured":"B. 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