{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:00:17Z","timestamp":1775890817166,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The leaves of\n                    <jats:italic>Ehretia asperula<\/jats:italic>\n                    were extracted with ethanol to obtain a crude extract, which was evaluated for its anti\u2010hyperglycemic activity.\n                    <jats:italic>E. asperula<\/jats:italic>\n                    was investigated using in vitro assays (\u03b1\u2010amylase and \u03b1\u2010glucosidase) and a diabetic mouse model induced by alloxan monohydrate (AM). The extract exhibited inhibitory activity against \u03b1\u2010glucosidase (half\u2010maximal inhibitory concentration [IC\n                    <jats:sub>50<\/jats:sub>\n                    ] value of 29.75\u00a0\u00b5g\/mL) and \u03b1\u2010amylase (IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 136.71\u00a0\u00b5g\/mL). The\n                    <jats:italic>E. asperula<\/jats:italic>\n                    extract also showed no toxicity in both acute and sub\u2010chronic toxicity studies. Administration of the extract at a concentration of 400\u00a0mg\/kg body weight effectively modulated and reduced blood glucose levels in AM\u2010induced diabetic mice. Moreover, the extract improved glucose metabolism in diabetic mice by increasing the number of functional cells within the islets of Langerhans and reducing pancreatic damage. Additionally,\n                    <jats:italic>E. asperula<\/jats:italic>\n                    extract regulated blood lipid levels, liver enzymes, and cardiovascular indices in diabetic mice. These findings suggest that\n                    <jats:italic>E. asperula<\/jats:italic>\n                    possesses promising antidiabetic potential and warrants further investigation as a source of bioactive natural products.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501933","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:29:18Z","timestamp":1765391358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antidiabetic and Toxicological Evaluation of\n                    <i>Ehretia asperula<\/i>\n                    Leaf Extract in Diabetic Mice"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-5526","authenticated-orcid":false,"given":"Yen D. H.","family":"Nguyen","sequence":"first","affiliation":[{"name":"NTT Hi\u2010Tech Institute Nguyen Tat Thanh University  Ho Chi Minh City Vietnam"},{"name":"Nguyen Tat Thanh University Center for Hi\u2010Tech Development Saigon Hi\u2010Tech Park  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Chi","family":"Linh","sequence":"additional","affiliation":[{"name":"Nam Can Tho University  Can Tho Vietnam"},{"name":"Faculty of Medicine Nam Can Tho University  Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Trong","family":"Tuan","sequence":"additional","affiliation":[{"name":"College of Natural Sciences Can Tho University  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luu Thai","family":"Danh","sequence":"additional","affiliation":[{"name":"College of Agriculture Can Tho University  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0942-7081","authenticated-orcid":false,"given":"Dai Thi Xuan","family":"Trang","sequence":"additional","affiliation":[{"name":"College of Natural Sciences Can Tho University  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.21608\/jbaar.2024.382794"},{"key":"e_1_2_9_3_1","volume-title":"IDF Diabetes Atlas: 11th Edition\u2014Global Factsheet","author":"International Diabetes Federation","year":"2025"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.14042"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajm.ajm_53_20"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.47672\/ejb.409"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20100407.70014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8609213"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3706508"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010061"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.800714"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5594386"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27134278"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2144\/fsoa\u20102021\u20100109"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X211067986"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.25258\/ijddt.14.1.60"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.56042\/ijnpr.v12i4.29108"},{"key":"e_1_2_9_18_1","article-title":"The Antihyperglycemic, Antioxidant and Antimicrobial Activities of Ehretia cymosa","author":"Sarkodie J. 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