{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:48:33Z","timestamp":1788922113326,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In the present study, we aimed to evaluate the antinociceptive potential of the\n                    <jats:italic>Pectis elongata<\/jats:italic>\n                    essential oil (PeEO) and to understand its mechanism of action by identifying possible pain inhibition pathways. PeEO was analyzed using gas chromatography coupled with mass spectrometry. Male Swiss mice were subjected to the hot plate test to assess analgesic activity, determine the effective dose, and elucidate the pharmacological pathways involved, using specific blockers of the opioid, cholinergic, and nitric oxide pathways. Chemical analysis identified 23 compounds accounting for 95.57% of the sample, with citral (86.4%\u2014Geranial and Neral) as the major constituent. The antinociceptive activity of PeEO was observed at a dose of 600\u00a0mg\/kg, and this effect was mediated by the opioid and nitrergic pathways, as evidenced by pretreatment with L\u2010NAME and naloxone. These findings reinforce the analgesic potential of PeEO, possibly related to its high citral content.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501962","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:47:20Z","timestamp":1761126440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Opioid and Nitrergic Pathways Mediate Antinociception by\n                    <i>Pectis elongata<\/i>\n                    Kunth. Essential Oil"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-795X","authenticated-orcid":false,"given":"Angela Palma","family":"Amorin","sequence":"first","affiliation":[{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Layse Ferreira","family":"Sarrazin","sequence":"additional","affiliation":[{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"},{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade e Biotecnologia Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"},{"name":"Programa De Ci\u00eancias Naturais, Instituto de Ci\u00eancias da Educa\u00e7\u00e3o Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6081-2623","authenticated-orcid":false,"given":"Leomara Andrade","family":"da Silva","sequence":"additional","affiliation":[{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9039-7121","authenticated-orcid":false,"given":"Thaiana Neves","family":"Coelho","sequence":"additional","affiliation":[{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-5138","authenticated-orcid":false,"given":"Adriele Pantoja","family":"Cunha","sequence":"additional","affiliation":[{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8020-6185","authenticated-orcid":false,"given":"Vit\u00f3ria Albuquerque","family":"de Lima","sequence":"additional","affiliation":[{"name":"Programa De Ci\u00eancias Naturais, Instituto de Ci\u00eancias da Educa\u00e7\u00e3o Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8619-1332","authenticated-orcid":false,"given":"Domingas Machado","family":"da Silva","sequence":"additional","affiliation":[{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade e Biotecnologia Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-3513","authenticated-orcid":false,"given":"Pablo Luis Baia","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade e Biotecnologia Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"},{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Par\u00e1  Belem Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4526-2146","authenticated-orcid":false,"given":"Ricardo Bezerra","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"},{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade e Biotecnologia Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"},{"name":"Programa De Ci\u00eancias Naturais, Instituto de Ci\u00eancias da Educa\u00e7\u00e3o Universidade Federal do Oeste do Par\u00e1  Santarem Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001939"},{"key":"e_1_2_9_3_1","first-page":"249","article-title":"Pain Terms: A List With Definitions and Notes on Usage. 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