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Though\n                    <jats:italic>Iphiona<\/jats:italic>\n                    plants have a history of usage among local people, the research on their phytochemistry or biological activity has been limited to some studies in recent years. This review aimed to collect the present data about\n                    <jats:italic>Iphiona<\/jats:italic>\n                    species and introduce these plants as interesting candidates for future studies. The published studies up to March 2025 were collected from Web of Science, PubMed, Scopus, and Google Scholar. The keywords included: Iphiona AND ethnobotany, ethnomedicine, traditional medicine, natural molecule, food, pharmacology, phytochemistry, compounds, biological activity, therapeutic potential, natural medicine, mechanism of action, phytochemicals, secondary metabolites, primary metabolites, alkaloid, flavonoid, terpenoid, polyphenol, monoterpene, sesquiterpene, essential oil, steroid, resin, gum, polysaccharide, oil, protein, mineral, vitamin, fatty acid, supplement, nutrition, meta\u2010analysis, clinical trial, toxicity, and side effects. The evaluated studies revealed the presence of terpenoids, flavonoids, chlorogenic acid derivatives and phyosterols as the most dominant constituents found in the plants. Antioxidant, antimicrobial, antifungal, cytotoxic, hepatoprotective, and \u03b1\u2010amylase inhibitory activity have been reported from the plants of\n                    <jats:italic>Iphiona<\/jats:italic>\n                    genus. This review suggests\n                    <jats:italic>Iphiona<\/jats:italic>\n                    as an important, interesting, novel genus, yet to be explored for secondary metabolites and biological activities.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501967","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:32:40Z","timestamp":1773394360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Review of the Ethnobotany, Biological Activity, and Bioactive Compounds of the Plants in the\n                    <i>Iphiona<\/i>\n                    Genus"],"prefix":"10.1002","volume":"23","author":[{"given":"Maryam","family":"Hamzeloo\u2010Moghadam","sequence":"first","affiliation":[{"name":"Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ardalan","family":"Pasdaran","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Paslari","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Pharmacy Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Hossein","family":"Rasti","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Pharmacy Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Kozuharova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Medical University of Sofia  Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-6730","authenticated-orcid":false,"given":"Azadeh","family":"Hamedi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Medicinal Plants Processing Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Iphiona Cass \u201cPlants of the World Online. Facilitated by the Royal Botanic Gardens Kew.\u201d (2025) Published on the Internet at https:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names:331674\u20102in."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756\u20101051.1985.tb02086.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2013.879573"},{"key":"e_1_2_11_5_1","first-page":"28","article-title":"Novel Pharmacological Properties of Iphiona scabra and Jasonia montana (Asteraceae) Aqueous Extracts: Screening for Anti\u2010Platelet Aggregation, Anti\u2010Inflammatory and Hypotensive Effects in Albino Rats","author":"Nada A.","year":"2006","journal-title":"Egyptian Medical Journal of the National Research Center"},{"key":"e_1_2_11_6_1","first-page":"305","article-title":"Hepatoprotective Activity of Iphiona grantioides and Pluchea arguta for Acetaminophen Induced Toxicity in Rabbits","volume":"20","author":"Naveed S.","year":"2014","journal-title":"Pakistan Journal of Weed Science Research"},{"key":"e_1_2_11_7_1","first-page":"13","article-title":"Anthelmintic, Antilice, Insecticidal, Cytotoxic and Phytotoxic Potential of Ethanolic Extracts of Two Wild Medicinal Plants Iphiona grantioides and Pluchea arguta","volume":"23","author":"Khan M. I.","year":"2016","journal-title":"Medicinal Plant"},{"key":"e_1_2_11_8_1","first-page":"2505","article-title":"In vitro Evaluation of Medicinal, Antioxidant Activities and Phytochemical Screening of Iphiona grantioides and Pluchea arguta subsp. glabra qaiser","volume":"48","author":"Naveed S.","year":"2016","journal-title":"Pakistan Journal of Botany"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301932"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2023.02.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13071589"},{"key":"e_1_2_11_12_1","unstructured":"F. G.Valiollah Mozaffarian S.Narimisa E.Jafari S.Kazempour\u2010Osaloo E.Lotfi andM.Asadi Flora of Iran No. 144 (Asteraceae) (Research Institute of Forests and Rangelands 2018)."},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.22244\/rheedea.2011.21.01.04","article-title":"Cypsela Morphology and Anatomy in Some Genera Formerly Placed in Inula (Asteraceae: Inuleae\u2010Inulinae)","volume":"21","author":"Shekhar S.","year":"2011","journal-title":"Rheedea"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X20903555","article-title":"Advances in Pharmacological Activities of Terpenoids","volume":"15","author":"Yang W.","year":"2020","journal-title":"Natural Products Communications"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2008.10643630"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74075-6_19"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcx123"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-22144-6_129"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2004.9698802"},{"key":"e_1_2_11_21_1","first-page":"278","article-title":"Toxic Dipertene Glycosides From Iphiona aucheri","volume":"68","author":"Wernery U.","year":"1997","journal-title":"Fitoterapia"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109422(94)85060\u20107"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217529"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1515\/znb\u20101985\u20101134"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50070a047"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.22034\/jmpb.2024.367490.1798"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2023.2272782"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(00)97945\u20107"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(00)81428\u20104"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(00)81848\u20108"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10298\u2010014\u20100897\u20108"},{"key":"e_1_2_11_32_1","first-page":"1823","article-title":"Essential oil Composition of Iphiona scabra (DC) grow wild in Egypt","volume":"23","author":"Ibrahim M.","year":"2016","journal-title":"International Food Research Journal"},{"key":"e_1_2_11_33_1","first-page":"51","article-title":"Phytochemical and Some Pharmacological Properties of Certain Plants Belonging to Asteraceae Family","volume":"7","author":"Awatef M. 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