{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:22:44Z","timestamp":1791415364334,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Magnoliae flos<\/jats:italic>\n                    (Shin\u2010i) has been traditionally utilized in Chinese medicine for rhinitis, sinusitis, and headaches. However, the underlying anti\u2010inflammatory mechanisms of Shin\u2010i essential oil (SIEO), especially its effects on the Janus kinase\/signal transducer and activator of transcription (JAK\u2013STAT) signaling pathway, remain inadequately elucidated. The chemical composition of SIEO was characterized using gas chromatography\u2013mass spectrometry (GC\u2013MS). Network pharmacology and gene ontology (GO) enrichment analyses predicted that SIEO may target the JAK\u2013STAT signaling pathway. Cellular experiments revealed that the excellent anti\u2010inflammatory effects of SIEO were dose\u2010dependent and attributed to the main component, eucalyptol, which reduced nitric oxide (NO) levels and reactive oxygen species (ROS), respectively. Molecular docking results indicated favorable binding affinities between eucalyptol and both JAK1 and STAT1. Western blot analysis further confirmed that SIEO and eucalyptol inhibited the phosphorylation levels of JAK1 to 68.63% and 84.43%, respectively, STAT1 to 47.61% and 74.90%, respectively, and inducible nitric oxide synthase (iNOS) expression to 38.70% and 74.58%, respectively. Therefore, it is suggested that the component eucalyptol plays a key role in the anti\u2010inflammatory functions of SIEO, acting via the JAK1\/STAT1\/iNOS axis. This study provided insights for the research on the anti\u2010inflammatory mechanisms of SIEO and suggested its potential application prospects in functional cosmetics and medical care.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501983","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:53:12Z","timestamp":1772967192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Magnoliae flos<\/i>\n                    (Shin\u2010i) Essential Oil and Its Principal Component Eucalyptol Inhibit JAK1 to Counteract the LPS\u2010Induced RAW264.7 Inflammation"],"prefix":"10.1002","volume":"23","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"School of Perfume &amp; Aroma and Cosmetics Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Perfume &amp; Aroma and Cosmetics Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghui","family":"Ou","sequence":"additional","affiliation":[{"name":"School of Perfume &amp; Aroma and Cosmetics Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gege","family":"Jiao","sequence":"additional","affiliation":[{"name":"School of Perfume &amp; Aroma and Cosmetics Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Perfume &amp; Aroma and Cosmetics Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingping","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Life Sciences &amp; Biotechnology, Institute of Mechanobiology &amp; Medical Engineering Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3335-5062","authenticated-orcid":false,"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Perfume &amp; Aroma and Cosmetics Shanghai Institute of Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105087"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104044"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515002093"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127605"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116851"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.01.038"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115846"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501111"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0898\u20106568(00)00149\u20102"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/341308"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114493"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151239498"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.1097"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2013.06.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2016.09.009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.10.008"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.117131"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2019.1645256"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.140920"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2020.112329"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15081930"},{"key":"e_1_2_8_23_1","volume-title":"Chinese Herbal Medicine: Materia Medica, Revised Edition","author":"Bensky D.","year":"1993"},{"key":"e_1_2_8_24_1","volume-title":"Pharmacopoeia of the People's Republic of China Chemical Industry","author":"C. 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