{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:27:32Z","timestamp":1784820452299,"version":"3.55.0"},"reference-count":91,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hyperlipidemia, a major risk factor for ischemic heart disease, is commonly managed with statins, which, despite their efficacy, are associated with adverse effects such as myopathy. This study evaluated the antihyperlipidemic potential of\n                    <jats:italic>Thymus linearis<\/jats:italic>\n                    extract (250 and 500\u00a0mg\/kg body weight) in Swiss albino mice (six groups,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a05) fed a high\u2010cholesterol diet. Biological parameters, including body weight, glycemic indices, lipid profile, biochemical markers, and histopathological changes in the liver and kidney, were assessed. Phytochemical profiling using GC\u2013MS revealed the presence of 12 bioactive compounds. Molecular docking confirmed the strong binding affinities of the metabolites to key targets, including the peroxisome proliferator\u2010activated receptor (PPAR\u2010\u03b1), HMG\u2010CoA reductase, and acyl\u2010CoA:cholesterol acyltransferase (ACAT). Density functional theory (DFT) calculations further supported the docking results. MM\/GBSA analysis showed that compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>11<\/jats:bold>\n                    , and\n                    <jats:bold>12<\/jats:bold>\n                    exhibited binding energies of \u221273.13, \u221252.51, and \u221213.83\u00a0kcal\/mol, respectively. ADMET studies indicated that, except for compounds\n                    <jats:bold>5<\/jats:bold>\n                    ,\n                    <jats:bold>10<\/jats:bold>\n                    , and\n                    <jats:bold>12<\/jats:bold>\n                    , all compounds complied with Lipinski's rule of five. Histological analyses revealed reduced adipocyte and hepatocyte sizes, indicating suppressed adipogenesis and improved hepatic architecture. In conclusion, the extract at 500\u00a0mg\/kg improved lipid profiles and enhanced insulin sensitivity, comparable to simvastatin (1.5\u00a0mg\/kg).\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501986","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T17:30:47Z","timestamp":1766251847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical Profiling, In Vivo Evaluation, and In Silico Insights Into the Antihyperlipidemic Potential of\n                    <i>Thymus linearis<\/i>\n                    Extract"],"prefix":"10.1002","volume":"23","author":[{"given":"Sumaira","family":"Saleem","sequence":"first","affiliation":[{"name":"Department of Chemistry Institute of Chemical Sciences Government College University Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Naseer","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering Syed Babar Ali School of Science &amp; Engineering (SBASSE) Lahore University of Management Sciences (LUMS)  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimra","family":"Arif","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering Syed Babar Ali School of Science &amp; Engineering (SBASSE) Lahore University of Management Sciences (LUMS)  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Wajid","sequence":"additional","affiliation":[{"name":"Gulab Devi Institute of Pharmacy Gulab Devi Educational Complex  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-9921","authenticated-orcid":false,"given":"Gulzar","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Chemistry Institute of Chemical Sciences Government College University Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Government College University Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Arshad","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Chemistry Institute of Chemical Sciences Government College University Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Adeel","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences University of Veterinary and Animal Science  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamna","family":"Majeed","sequence":"additional","affiliation":[{"name":"Department of Chemistry Institute of Chemical Sciences Government College University Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020672"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312782"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202501066"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2016.1220393"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.42965"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1634517"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10050784"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","unstructured":"S.Bulut R.Toslak M. 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