{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:35:47Z","timestamp":1789104947074,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The global rise in antibiotic resistance demands the urgent development of new antibacterial agents. This study investigated the antibacterial potential of four synthesized methoxy and thiophene chalcone derivatives (designated\n                    <jats:bold>3a<\/jats:bold>\n                    ,\n                    <jats:bold>4a<\/jats:bold>\n                    ,\n                    <jats:bold>3b<\/jats:bold>\n                    , and\n                    <jats:bold>4b<\/jats:bold>\n                    ) against clinically relevant bacterial pathogens. These compounds were prepared through Claisen\u2010Schmidt condensation, while their chemical structures were verified through applying Fourier\u2010transform infrared, mass spectrometry,\n                    <jats:sup>1<\/jats:sup>\n                    H nuclear magnetic resonance (NMR), and\n                    <jats:sup>13<\/jats:sup>\n                    C NMR. Their antibacterial activity was tested in vitro, employing minimum inhibitory concentration (MIC) and well diffusion assays. Among these synthesized compounds,\n                    <jats:bold>3a<\/jats:bold>\n                    demonstrated the strongest antibacterial efficacy, showing notable inhibition zones and low MIC values against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    , suggesting an increased effectiveness against Gram\u2010negative strains. Molecular docking studies targeting Penicillin\u2010Binding Protein 4 from\n                    <jats:italic>S. aureus<\/jats:italic>\n                    indicated robust binding affinities, with\n                    <jats:bold>3a<\/jats:bold>\n                    and\n                    <jats:bold>4a<\/jats:bold>\n                    exhibiting interactions comparable to or even exceeding ampicillin. Additionally, computational Absorption, Distribution, Metabolism, Excretion, and Toxicity analysis confirmed promising pharmacokinetics, such as adherence with Lipinski's Rule of Five, high gastrointestinal absorption, and low toxicity profiles. These insights emphasize a great potential in the synthesized derivatives for further advancement in addressing multidrug\u2010resistant bacterial infections, and potentially expanding the range of effective antibacterial drugs.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502016","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T19:53:45Z","timestamp":1757447625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Methoxy and Thiophene Chalcone Derivatives Against Multidrug\u2010resistant Bacteria: Synthesis, in Vitro Evaluation, and Molecular Docking Insights"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-1933","authenticated-orcid":false,"given":"Sara Ramzi","family":"Abdulhameed","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy University of Sulaimani  Sulaimani Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3719-2099","authenticated-orcid":false,"given":"Narmin Hamaamin","family":"Hussen","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy University of Sulaimani  Sulaimani Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-6127","authenticated-orcid":false,"given":"Tavga Ahmed","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy University of Sulaimani  Sulaimani Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1173-5512","authenticated-orcid":false,"given":"Hozan Jaza Hama","family":"Salh","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy University of Sulaimani  Sulaimani Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"01","volume":"13","author":"Yu D.","year":"2023","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"issue":"4","key":"e_1_2_7_3_1","first-page":"277","article-title":"The Antibiotic Resistance Crisis: Part 1: Causes and Threats","volume":"40","author":"Ventola C. 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