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Molecules from nature are a prolific source of anticancer molecules. This study aimed to discover new anticancer molecules from\n                    <jats:italic>Gambeya lacourtiana<\/jats:italic>\n                    stem bark extract using in vitro assays. Complete assignment of the NMR data of 3, 5, 7, 3\n                    <jats:italic>'<\/jats:italic>\n                    , 5\n                    <jats:italic>'<\/jats:italic>\n                    \u2010pentahydroxy\u20104\n                    <jats:italic>'<\/jats:italic>\n                    \u2010methoxyflavane or 4\n                    <jats:italic>'<\/jats:italic>\n                    \u2010methoxyepigallocatechin (\n                    <jats:bold>1<\/jats:bold>\n                    ) isolated from the stem bark of\n                    <jats:italic>G. lacourtiana<\/jats:italic>\n                    along with (\u2010)\u2010epicatechin (\n                    <jats:bold>2<\/jats:bold>\n                    ),\n                    <jats:italic>\u00a0\u03b2<\/jats:italic>\n                    \u2010amyrin pentanoate (\n                    <jats:bold>3<\/jats:bold>\n                    ),\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amyrin acetate (\n                    <jats:bold>4<\/jats:bold>\n                    ),\u00a0lupeol acetate (\n                    <jats:bold>5<\/jats:bold>\n                    ), taraxerol (\n                    <jats:bold>6<\/jats:bold>\n                    ), 28\u2010hydroxyl\u20103\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010amyrin (\n                    <jats:bold>7<\/jats:bold>\n                    ), euscaphic acid (\n                    <jats:bold>8<\/jats:bold>\n                    ), betulinic acid (\n                    <jats:bold>9<\/jats:bold>\n                    ), chondrillasterol (\n                    <jats:bold>10<\/jats:bold>\n                    ), and 3\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010D\u2010glucopyranosyl chondrillasterol (\n                    <jats:bold>11<\/jats:bold>\n                    ) was achieved. Structures were elucidated by the interpretation of their NMR and spectrometric data in conjunction with literature data. In vitro cytotoxicity carried out on isolates toward CCRF\u2010CEM revealed only compound\n                    <jats:bold>1<\/jats:bold>\n                    to be moderately cytotoxic (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a029.45\u00a0\u00b5g\/mL). PASS analysis suggested that the isolated compounds had antineoplastic, antiproliferative, anti\u2010inflammatory, hepatoprotective, chemopreventive, membrane integrity agonist, mucomembranous protector, insulin promoter, fibrinolytic, and antioxidant effects. In addition, isolates were projected to treat hepatic disorders, leishmaniasis, wounds, proliferative diseases, capillary fragility, hypercholesterolemia, influenza, eczema, and leukemia. Predictions on its inhibition of testosterone 17\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010dehydrogenase (NADP+), a key enzyme involved in androgen metabolism, corroborate the use of this plant traditionally to solve reproductive health issues.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502045","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:31:21Z","timestamp":1778477481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Natural Products in\n                    <i>Gambeya lacourtiana<\/i>\n                    (Sapotaceae): Identification, In Vitro Cytoxicity, and Deep Learning\u2010Based Pharmacokinetic Prediction"],"prefix":"10.1002","volume":"23","author":[{"given":"Marcelle O.","family":"Ngangoue","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Faculty of Science University of Yaound\u00e9 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