{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:10:44Z","timestamp":1773493844962,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Phytochemical investigation of the 95% ethanol extract of the whole plants of\n                    <jats:italic>Isodon serra<\/jats:italic>\n                    (Lamiaceae) led to the isolation of a new\n                    <jats:italic>ent<\/jats:italic>\n                    \u2010kaurane diterpenoid isoserrone A (\n                    <jats:bold>1<\/jats:bold>\n                    ) and a new 2,3\u2010\n                    <jats:italic>seco<\/jats:italic>\n                    \u2010ursane\u2010type triterpenoid isoserric acid A (\n                    <jats:bold>2<\/jats:bold>\n                    ), along with four known compounds (\n                    <jats:bold>3<\/jats:bold>\n                    \u2013\n                    <jats:bold>6<\/jats:bold>\n                    ). Except for compound\n                    <jats:bold>4<\/jats:bold>\n                    , the remaining compounds were obtained from\n                    <jats:italic>I. serra<\/jats:italic>\n                    for the first time. The structures of the new compounds were established based on the analysis of HRESIMS, IR, 1D, and 2D NMR spectroscopic data. The absolute configurations of\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    were elucidated by electronic circular dichroism (ECD) and single\u2010crystal X\u2010ray diffraction analysis, respectively. To our knowledge, this article provides the first reported single\u2010crystal X\u2010ray diffraction data of known compounds\n                    <jats:bold>4<\/jats:bold>\n                    \u2013\n                    <jats:bold>6<\/jats:bold>\n                    . Moreover, using a transgenic\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    Alzheimer's disease (AD) pathological model, we evaluated the in vivo anti\u2010AD activities of compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    . The biological evaluation revealed that\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    delayed the paralysis process in CL4176 nematodes at the concentration of 100\u00a0\u00b5M, suggesting their potential as anti\u2010AD therapeutic candidates.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502057","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:28:24Z","timestamp":1758821304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two New Terpenoids From\n                    <i>Isodon serra<\/i>\n                    and Their Anti\u2010Alzheimer's Disease Activity"],"prefix":"10.1002","volume":"22","author":[{"given":"Li\u2010Jia","family":"Ye","sequence":"first","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Applied Organic Chemistry Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Applied Organic Chemistry Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi\u2010Na","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Applied Organic Chemistry Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Applied Organic Chemistry Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Nan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Applied Organic Chemistry Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Fen","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Applied Organic Chemistry Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Applied Organic Chemistry Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7892-9851","authenticated-orcid":false,"given":"Zhan\u2010Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Applied Organic Chemistry Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-8347","authenticated-orcid":false,"given":"Dong\u2010Qing","family":"Fei","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Applied Organic Chemistry Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.766581"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/B604174D"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2014.03.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2013.837458"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337\u2010005\u20100590\u2010z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2018.05.017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24152736"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200497"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1421"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.03.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2024.114247"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2020.1841189"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010024\u201000432\u2010x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1484373"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076518"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.10.060"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.05.029"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2016.05.014"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01281"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600\u2010025\u201004687\u20102"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.2c01136"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115527"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(00)81969\u2010X"},{"key":"e_1_2_9_26_1","first-page":"16","article-title":"Diterpenoids From Isodon japonicus","volume":"1","author":"Han Q. B.","year":"2003","journal-title":"Chinese Journal of Natural Medicines"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109422(75)85047\u20103"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010food\u2010030117\u2010012709"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00361"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.955113"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3791\/2252\u2010v"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2025.155519"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202502057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:49:46Z","timestamp":1773488986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202502057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/cbdv.202502057"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202502057","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,25]]},"assertion":[{"value":"2025-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02057"}}