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This work aimed at investigating the osteoformative effects of the\n                    <jats:italic>P. curatellifolia<\/jats:italic>\n                    aqueous leaves and bark mixture extract on malaria\u2010induced bone alterations. The in vitro antiplasmodial activity of the extract was assessed on\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    3D7 and Dd2. The phytochemical characterization of the extract and its fractions was carried out using LC\u2013MS technique. The in vivo study was evaluated using\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    ANKA\u2010induced malaria and bone disorders. Parasitemia was monitored, and hematological, biochemical, immunological, and histopathological parameters were assessed. The docking study was performed on\n                    <jats:italic>Pf<\/jats:italic>\n                    20S, TyrRS, MyD88, and RANKL using the Molecular Operating Environment 14. The extract exhibited in vitro antiplasmodial activity on\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    3D7 and Dd2 strains. The LC\u2013MS analysis of the extract and fractions revealed several peaks, of which 12 were characterized. The extract reduced parasitemia (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), improved hematological parameters, corrected malaria\u2010induced bone damage by increasing (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) bone osteocalcin, TGF\u2010\u03b21, ALP activity, mineralization, as well as reversing\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    \u2010induced inflammation. Likewise, the identified compounds exhibited strong inhibitory binding potential. These findings support the ability of the extract to correct malaria\u2010related bone disorders by acting as an antiplasmodial, osteoprotective, anti\u2010inflammatory, and antioxidant agent.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502120","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:54:01Z","timestamp":1761702841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Osteoprotective Effects and In Silico Profiling of\n                    <i>Parinari curatellifolia<\/i>\n                    Planch. Ex Benth. (Chrysobalanaceae) Extract on Acute\n                    <i>Plasmodium berghei<\/i>\n                    \u2010Compromised Rat Bone"],"prefix":"10.1002","volume":"23","author":[{"given":"Josiane","family":"Jouonzo","sequence":"first","affiliation":[{"name":"Department of Animal Biology and Physiology, Faculty of Science University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raceline Gounoue","family":"Kamkumo","sequence":"additional","affiliation":[{"name":"Department of Animal Biology and Physiology, Faculty of Science University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-9184","authenticated-orcid":false,"given":"Florence Tsofack","family":"Ngueguim","sequence":"additional","affiliation":[{"name":"Department of Animal Biology and Physiology, Faculty of Science University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noella Molisa","family":"Efange","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Buea  Buea Cameroon"},{"name":"Centre Pasteur du Cameroun  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvestre Saidou","family":"Tsila","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Higher Teacher Training College University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Dupon Akamba","family":"Ambamba","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science University of Yaound\u00e9 1  Yaound\u00e9 Cameroon"},{"name":"Center of Nutrition and Functional Foods  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith Laure","family":"Ngondi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science University of Yaound\u00e9 1  Yaound\u00e9 Cameroon"},{"name":"Center of Nutrition and Functional Foods  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Ayong","sequence":"additional","affiliation":[{"name":"Centre Pasteur du Cameroun  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Ndjakou","family":"Lenta","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Higher Teacher Training College University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobert","family":"Sewald","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Science University of Bielefeld  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9ophile","family":"Dimo","sequence":"additional","affiliation":[{"name":"Department of Animal Biology and Physiology, Faculty of Science University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"WHO World Malaria Report 2020(WHO 2020)."},{"key":"e_1_2_12_3_1","unstructured":"WHO World Malaria Report 2023(WHO 2023)."},{"key":"e_1_2_12_4_1","unstructured":"WHO World Malaria Report 2024(WHO 2024)."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2020.12.101"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12984"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-285"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-520767"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam8093"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxx076"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-021-03792-1"},{"key":"e_1_2_12_12_1","unstructured":"C.Coban \u201cMalaria and Vitamin D \u201d paper presented at the 4th Japanese Society of Osteoimmunology Meeting Okinawa Japan June 24\u201326 2018."},{"key":"e_1_2_12_13_1","first-page":"75","volume-title":"Les fruitiers forestiers comestibles du Cameroun","author":"Eyog M. 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