{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:04:21Z","timestamp":1780085061584,"version":"3.54.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Three new phthalide derivatives, named dicymalides A\u2013C (\n                    <jats:bold>1\u20133<\/jats:bold>\n                    ), were isolated from the mangrove endophytic fungus\n                    <jats:italic>Dicyma<\/jats:italic>\n                    sp. L6B1, together with eight known compounds. The structures of these compounds were elucidated by high\u2010resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopic data, single\u2010crystal X\u2010ray diffraction analysis, and specific rotation quantum\u2010chemical calculations. Inhibitory activities of\n                    <jats:bold>1\u201311<\/jats:bold>\n                    against nitric oxide production in lipopolysaccharide\u2010stimulated RAW264.7 cells were evaluated. Compound\n                    <jats:bold>8<\/jats:bold>\n                    exhibited potent inhibitory activity with a half\u2010maximal inhibitory concentration value of 1.0\u00a0\u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502240","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T18:55:52Z","timestamp":1756493752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dicymalides A\u2013C: Three New Phthalide Derivatives From the Mangrove Endophytic Fungus\n                    <i>Dicyma<\/i>\n                    sp. L6B1"],"prefix":"10.1002","volume":"22","author":[{"given":"Xiao","family":"Xiao","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai\u2010Lian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Natural Drugs Research and Development, The First Dongguan Affiliated Hospital, School of Pharmacy Guangdong Medical University  Dongguan China"},{"name":"Dongguan Key Laboratory For Marine Innovative Drugs and Bioproducts Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Wen","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0807-5229","authenticated-orcid":false,"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Natural Drugs Research and Development, The First Dongguan Affiliated Hospital, School of Pharmacy Guangdong Medical University  Dongguan China"},{"name":"Dongguan Key Laboratory For Marine Innovative Drugs and Bioproducts Guangdong Medical University  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"127","volume-title":"Progress in the Chemistry of Organic Natural Products","author":"Le\u00f3n A.","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2022.105223"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28083636"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2013.805235"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13659-025-00512-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.129.855"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/np1003752"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b05479"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b00017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00041A"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppa.12916"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0341204"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b02906"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10575639708043728"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.20307\/nps.2015.21.4.227"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-021-03316-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2023.113722"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.57.236"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2008.03.018"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2012.01.009"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2007.01.013"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<490::AID-JCC1>3.0.CO;2-P"}],"container-title":["Chemistry &amp; 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