{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:57:26Z","timestamp":1785488246068,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1515120075"],"award-info":[{"award-number":["2022B1515120075"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two new natural 2\u2010alkylquinolin\u20104(1\n                    <jats:italic>H<\/jats:italic>\n                    )\u2010one derivatives, 2\u2010(5\u2010methylheptyl) quinolin\u20104(1\n                    <jats:italic>H<\/jats:italic>\n                    )\u2010one (\n                    <jats:bold>1<\/jats:bold>\n                    ) and 2\u2010(5\u2010methylnonane) quinolin\u20104(1\n                    <jats:italic>H<\/jats:italic>\n                    )\u2010one (\n                    <jats:bold>2<\/jats:bold>\n                    ), along with ten known compounds (\n                    <jats:bold>3<\/jats:bold>\n                    \u2013\n                    <jats:bold>12<\/jats:bold>\n                    ), were isolated from the strain of\n                    <jats:italic>Bacillus rugosus<\/jats:italic>\n                    SCSIO 41395, which was obtained from the sediments of the Philippine Basin. All the isolates were evaluated for bacteriostatic activities against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    (PA). Compounds\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    exhibited bacteriostatic effects by inhibiting the expression of\n                    <jats:italic>rhl<\/jats:italic>\n                    ,\n                    <jats:italic>pqs<\/jats:italic>\n                    , and\n                    <jats:italic>las<\/jats:italic>\n                    quorum\u2010sensing genes, as well as suppressing related phenotypes, including rhamnolipid, pyocyanin production, and biofilm formation. Our findings suggest that compounds\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    are promising quorum\u2010sensing inhibitors for potential alternative treatments of PA infections.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502246","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:57:32Z","timestamp":1768071452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quinolinone and Amicoumacin Derivatives From the Deep Sea\u2010Derived\n                    <i>Bacillus rugosus<\/i>\n                    SCSIO 41395 and Their Bacteriostatic Activities Against\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Yuan","family":"Yuan","sequence":"first","affiliation":[{"name":"Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, State Key Laboratory of Tropical Oceanography Chinese Academy of Sciences  Guangzhou China"},{"name":"College of Chemical Engineering Department of Pharmaceutical Engineering Northwest University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Jia","sequence":"additional","affiliation":[{"name":"Shenzhen Third People's Hospital, National Clinical Research Centre for Infectious Disease, The Second Affiliated Hospital of Southern"},{"name":"School of Medicine Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyi","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Medicine Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Medicine Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, State Key Laboratory of Tropical Oceanography Chinese Academy of Sciences  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, State Key Laboratory of Tropical Oceanography Chinese Academy of Sciences  Guangzhou China"},{"name":"College of Chemical Engineering Department of Pharmaceutical Engineering Northwest University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Marine Materia Medica, South 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