{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:01:33Z","timestamp":1787162493220,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetes, a complicated metabolic disease, upsets glucose regulation and disturbs multiple organs, often resulting in problems like neuropathy and cardiovascular diseases. There is a pressing need to develop effective antidiabetic agents capable of managing glucose metabolism without compromising vital physiological functions. This study highlights the synthesis of 2\u2010thio\u20104\u2010quinazolinones (\n                    <jats:bold>5a<\/jats:bold>\n                    \u2013\n                    <jats:bold>j<\/jats:bold>\n                    ), the base\u2010catalyzed intramolecular cyclization of corresponding 2\u2010fluorobenzoyl\u20103\u2010aryl thioureas (\n                    <jats:bold>4a<\/jats:bold>\n                    \u2013\n                    <jats:bold>j<\/jats:bold>\n                    ), and their exploration for \u03b1\u2010 and \u03b2\u2010glucosidase inhibition. All the synthesized compounds exhibited strong \u03b1\u2010 and \u03b2\u2010glucosidase inhibition, with compound\n                    <jats:bold>5a<\/jats:bold>\n                    , containing chloro and nitro substituents, showing the most potent \u03b1\u2010glucosidase inhibition with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 1.89\u00a0\u00b1\u00a00.19\u00a0\u00b5M, markedly superior to that of the reference drug acarbose (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 9.80\u00a0\u00b1\u00a00.20\u00a0\u00b5M). Meanwhile, compound\n                    <jats:bold>5h<\/jats:bold>\n                    , featuring fluoro and chloro substituents, exhibited significant \u03b2\u2010glucosidase inhibition, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 0.95\u00a0\u00b1\u00a00.32\u00a0\u00b5M. Molecular docking validated the strong binding affinities of compounds\n                    <jats:bold>5a<\/jats:bold>\n                    and\n                    <jats:bold>5h<\/jats:bold>\n                    with \u03b1\u2010 and \u03b2\u2010glucosidase, exhibiting binding energies of \u221237.00 and \u221240.00\u00a0kJ\/mol, respectively, and DFT calculations elucidated their mode of action, electronic properties, and stability. In addition, the drug\u2010likeness analysis carried out through SwissADME established its pharmacologic feasibility. These results underline the amazing inhibitory potential of 2\u2010thio\u20104\u2010quinazolinones as promising lead candidates for the treatment of diabetes.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502283","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T17:40:16Z","timestamp":1763228416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Exploration of the Antidiabetic Potential of 2\u2010Thio\u20104\u2010quinazolinone Scaffolds Using In Vitro and In Silico Approaches"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7112-9296","authenticated-orcid":false,"given":"Aamer","family":"Saeed","sequence":"first","affiliation":[{"name":"Department of Chemistry Quaid\u2010i\u2010Azam University  Islamabad 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Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noorul","family":"Ain","sequence":"additional","affiliation":[{"name":"Department of Chemistry Quaid\u2010i\u2010Azam University  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Zaffar","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Management Health Services Academy Islamabad  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham R.","family":"El\u2010Seedi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Islamic University of Madinah  Madinah Saudi 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