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Using ultra\u2010high\u2010performance liquid chromatography with electrospray ionization mass spectrometry and gas chromatography, 41 compounds and five monosaccharides were identified. Antioxidant activity was confirmed in all extracts through the DPPH radical scavenging assay, with\n                    <jats:italic>S. schlechtendalianum<\/jats:italic>\n                    showing the highest activity, consistent with its elevated total polyphenol (94.4\u00a0mg\u00a0GAE\/g) and flavonoid (46.8\u00a0mg\u00a0QE\/g) contents. The anticancer potential was assessed against human breast (MCF\u20107, MDA\u2010MB\u2010231) and colorectal (HRT\u201018) cancer cell lines using the MTT assay. Among the samples,\n                    <jats:italic>S. crinitum<\/jats:italic>\n                    exhibited the greatest cytotoxicity against HRT\u201018 cells, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 58\u00a0\u00b5g\/mL and a selectivity index of 1.5, confirmed by clonogenic assays. Furthermore,\n                    <jats:italic>S. crinitum<\/jats:italic>\n                    significantly inhibited nitric oxide production (74%), cell migration (74%), and adhesion (52% and 30% on fibronectin and vitronectin, respectively), indicating notable anti\u2010metastatic potential. These results demonstrate that\n                    <jats:italic>Solanum<\/jats:italic>\n                    species, particularly\n                    <jats:italic>S. crinitum<\/jats:italic>\n                    and\n                    <jats:italic>S. schlechtendalianum<\/jats:italic>\n                    , are promising sources of bioactive compounds with antioxidant, anticancer, and anti\u2010metastatic properties, supporting their potential use in pharmaceutical and cosmetic industries.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502296","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T19:45:24Z","timestamp":1762631124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chemical Profiles and Bioactivities of Brazilian Amazonian\n                    <i>Solanum<\/i>\n                    Species: Antioxidant, Cytotoxic, and Anti\u2010Metastatic Properties"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-2521","authenticated-orcid":false,"given":"Juliana C.","family":"Atherino","sequence":"first","affiliation":[{"name":"Laboratory of Bacteriology Mycology and Cell Biology Federal University of Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8217-8907","authenticated-orcid":false,"given":"Eduarda C.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Pequeno Principe College Pel\u00e9 Pequeno Principe Research Institute  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2987-4147","authenticated-orcid":false,"given":"Gustavo T.","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy Federal University of Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6238-3604","authenticated-orcid":false,"given":"F\u00e1bio S.","family":"Murakami","sequence":"additional","affiliation":[{"name":"Quality Control Laboratory II Federal University of Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8862-4042","authenticated-orcid":false,"given":"Leandro L.","family":"Giacomin","sequence":"additional","affiliation":[{"name":"Laboratory of Plant Physiology and Evolution Department of Systematics and Ecology Center for Exact and Natural Sciences Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7125-7431","authenticated-orcid":false,"given":"Leopoldo C.","family":"Baratto","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Pharmacognosy Faculty of Pharmacy Federal University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9166-2146","authenticated-orcid":false,"given":"Lauro M.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Pequeno Principe College Pel\u00e9 Pequeno Principe Research Institute  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-4750","authenticated-orcid":false,"given":"Thalita G.","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy Federal University of Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-7936","authenticated-orcid":false,"given":"Wesley M.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Bacteriology Mycology and Cell Biology Federal University of Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203543"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx32"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5935\/1984\u20106835.20100006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2017.06.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajb2.1827"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tax.12990"},{"key":"e_1_2_9_9_1","volume-title":"Brasil: Solanum L. 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