{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:04:10Z","timestamp":1785341050432,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The whole plant of\n                    <jats:italic>Lysimachia paridiformis<\/jats:italic>\n                    var.\n                    <jats:italic>stenophylla<\/jats:italic>\n                    Franch. (known as \u201cKod tud vud\u201d in Chinese Miao medicine) has been used for the treatment of inflammation for a long time. However, its bioactive components and underlying mechanisms against inflammation are still unclear. The compounds were extracted and separated using silica gel chromatography, followed by further purification with Sephadex LH\u201020 and MCI gel CHP 20P. Their structures were identified through physical and chemical characteristics as well as spectral data. Network pharmacology was used to predict the potential anti\u2010inflammatory targets and pathways of these compounds, with the results validated through LPS\u2010induced cell models. A new lysilactone, 2,7,9\u2010trihydroxy\u20103\u2010methoxy\u20101\u2010methyl\u20106\n                    <jats:italic>H<\/jats:italic>\n                    \u2010benzo[\n                    <jats:italic>c<\/jats:italic>\n                    ]chromen\u20106\u2010one (\n                    <jats:bold>1<\/jats:bold>\n                    ), has been isolated from \u201cKod tud vud.\u201d In addition, five known compounds were obtained, including three lysilactone compounds, one diketopiperazine\u2010type indole alkaloid, and the diketopiperazine alkaloid 3,6\u2010diisopropyl\u20102,5\u2010diketopiperazine (\n                    <jats:bold>6<\/jats:bold>\n                    ). Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    significantly inhibited nitric oxide (NO) production and the expression of interleukin\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    (IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ), interleukin\u20106 (IL\u20106), tumor necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), cyclooxygenase\u20102 (COX\u20102), and inducible nitric oxide synthase (iNOS) in LPS\u2010induced macrophages. Mechanistic studies revealed that these effects were achieved by reducing p65 phosphorylation and preventing its nuclear translocation, thereby decreasing the activation of the NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B pathway. Overall, these findings suggest that compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    may be potential therapeutic agents for inflammation by inhibiting the NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B signaling pathway.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502340","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:10:01Z","timestamp":1775027401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory Mechanisms of Lysilactones and Diketopiperazine Alkaloids From\n                    <i>Lysimachia paridiformis<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Lulu","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"},{"name":"Guizhou Key Laboratory of Miao Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"},{"name":"School of Basic Medicine Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"},{"name":"Guizhou Key Laboratory of Miao Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghai","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"},{"name":"Guizhou Key Laboratory of Miao Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Sun","sequence":"additional","affiliation":[{"name":"Sinopharm Group Tongjitang (Guizhou) Pharmaceutical Co., Ltd.  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