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This study identifies Hui\u2010Xiang decoction (HXD), a formulation from food and medicine homology (FMH) herbs, as an effective and low\u2010toxicity treatment. We identified the presence of 122 active ingredients and 12\u00a0PC associated targets in HXD by network pharmacology. HXD and its active component, ammidin, effectively inhibited the proliferation and migration of PC cells. Furthermore, treatment with HXD in clinically relevant patient\u2010derived organoid (PDO) and xenograft (PDX) models significantly inhibited tumor growth, with minimal toxicity. Crucially, we found that HXD combats PC through a dual mechanism: simultaneously inhibiting the oncogenic EGFR\/ErbB2\/AKT1 pathway and activating the tumor\u2010suppressive Hippo signaling pathway. 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