{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:02:45Z","timestamp":1775890965995,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3506600"],"award-info":[{"award-number":["2024YFC3506600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Four novel compounds (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    ) and 22 known compounds (\n                    <jats:bold>5<\/jats:bold>\n                    \u2013\n                    <jats:bold>26<\/jats:bold>\n                    ) were obtained from the roots of\n                    <jats:italic>Arnebia euchroma<\/jats:italic>\n                    (Royle) Johnst. The four novel compounds are three quinones named euchronins K\u2010M (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>3<\/jats:bold>\n                    ), and one arnebinol compound, named arnebinol E (\n                    <jats:bold>4<\/jats:bold>\n                    ). The molecular architecture of the novel compounds was unambiguously established through systematic spectral characterization, including high\u2010resolution electrospray ionization mass spectrometry, ultraviolet, infrared, one\u2010 and two\u2010dimensional nuclear magnetic resonance experiments, and electronic circular dichroism for stereochemical verification. Cellular bioactivity profiling of these compounds was evaluated by us in this study. In vitro cell viability screening assays, the results showed that the compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    ,\n                    <jats:bold>10<\/jats:bold>\n                    ,\n                    <jats:bold>11<\/jats:bold>\n                    ,\n                    <jats:bold>15<\/jats:bold>\n                    ,\n                    <jats:bold>19<\/jats:bold>\n                    ,\n                    <jats:bold>20<\/jats:bold>\n                    , and\n                    <jats:bold>26<\/jats:bold>\n                    exhibited strong neuroprotective activity, with 50% effective concentration values ranging from 3.66 to 19.23 \u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502359","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:18:20Z","timestamp":1770326300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Neuroprotective Phytochemicals From the Roots of\n                    <i>Arnebia euchroma<\/i>\n                    : Isolation and Biological Evaluation"],"prefix":"10.1002","volume":"23","author":[{"given":"Jiatong","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education+Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First\u2010class Construction Interdiscipline)  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education+Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First\u2010class Construction Interdiscipline)  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao\u2010Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Guan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education+Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First\u2010class Construction Interdiscipline)  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Min","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education+Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First\u2010class Construction Interdiscipline)  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqi","family":"An","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education+Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First\u2010class Construction Interdiscipline)  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education+Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First\u2010class Construction Interdiscipline)  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education+Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First\u2010class Construction Interdiscipline)  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-775X","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixue","family":"Kuang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education+Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First\u2010class Construction Interdiscipline)  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education+Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First\u2010class Construction Interdiscipline)  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants14111669"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113896"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418\u2010023\u201001738\u20102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2024.114368"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.11.238"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2022.105288"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107691"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.108048"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286021003743861"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102006\u2010961439"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103655"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.08.021"},{"key":"e_1_2_10_14_1","first-page":"272","article-title":"Effects of Arnebia euchroma Extract on Streptozotocin Induced Diabetes in Rats: A Stereological Study","volume":"13","author":"Noorafshan A.","year":"2017","journal-title":"Acta Endocrinol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2020.1818793"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.33.Sup2a.xiv"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010020\u201003106\u2010z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115739"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.30.4407"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102006\u2010959704"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1545693"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2018.11.005"},{"key":"e_1_2_10_23_1","first-page":"1093","article-title":"Studies on Chemical Constituents From tibetan Medicine Elsholtzia","volume":"24","author":"Ding C. X.","year":"2004","journal-title":"Ianthina Acta Botanica Boreali\u2010Occidentalia Sinica"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101280266"},{"key":"e_1_2_10_25_1","first-page":"692","article-title":"Studies on Flavonoids From Stems and Leaves of Calophyllum inophyllum","volume":"32","author":"Li Y. Z.","year":"2007","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_10_26_1","first-page":"1149","article-title":"Research on the Chemical Composition of Melastoma dodecandrum Lour","volume":"39","author":"Tang M.","year":"2008","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3724\/SP.J.1143.2009.09031"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.01.002"},{"key":"e_1_2_10_29_1","first-page":"2701","article-title":"Chemical Constituents From the Roots of Arnebia euchroma","volume":"43","author":"Liao M.","year":"2020","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/np960127v"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.39.2956"},{"key":"e_1_2_10_32_1","first-page":"2607","article-title":"Chemical Constituents From Leaves of Dalbergia odorifera","volume":"45","author":"Shen C. X.","year":"2022","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600\u2010023\u201004155\u20109"},{"key":"e_1_2_10_34_1","first-page":"1390","article-title":"Research on the Chemical Components of Artemisia scoparia Waldst.\u2219Et Kit","volume":"30","author":"Xie T.","year":"2005","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1428589"},{"key":"e_1_2_10_36_1","first-page":"3627","article-title":"Chemical Constituents From Plumeria rubra and Their \u03b1\u2010glucosidase Inhibitory Activities","volume":"45","author":"Zhang S. N.","year":"2023","journal-title":"Chinese Traditional Patent Medicine"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50059a030"},{"key":"e_1_2_10_38_1","first-page":"5018","article-title":"Chemical Constituents From Argyreia Pierreana and Their Anti\u2010inflammatory Activities","volume":"55","author":"Teng M. X.","year":"2024","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_10_39_1","first-page":"1313","article-title":"Chemical Constituents From Hoya lyi","volume":"41","author":"Dai H. M.","year":"2019","journal-title":"Chinese Traditional Patent Medicine"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.33.3993"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.56.1687"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.10.009"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202502359","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:35:46Z","timestamp":1775889346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202502359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/cbdv.202502359"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202502359","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02359"}}