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Conventional treatments, such as glucocorticoid\u2010based immunosuppressive therapies, are associated with notable drawbacks and limitations. In response to these difficulties, recent scientific efforts have increasingly focused on natural compounds as potential therapeutic agents. This review explores the role of naturally derived small molecules, including flavonoids, alkaloids, terpenes, and glycosides, in addressing four common AIDs: multiple sclerosis (MS), inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and psoriasis (PSO). These compounds derived from plants exhibit diverse pharmacological effects that target multiple pathways, providing a strong foundation for their therapeutic applications. Although traditional therapies continue to play a crucial role, the integration of natural small molecules highlights the necessity of further research at cellular\u2010 and animal\u2010level studies with multi\u2010target approach to better understand their mechanisms of action for certain diseases in regulated pathways and optimize their practical application in clinical settings.<\/jats:p>","DOI":"10.1002\/cbdv.202502362","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T19:59:42Z","timestamp":1757447982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Natural Products for Regulation of Autoimmune Diseases: Chemical Diversity, Pharmacology, and Therapeutic Applications"],"prefix":"10.1002","volume":"22","author":[{"given":"Yueshi","family":"Sha","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Engineering Research Center of New Technologies and Applications 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