{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:00:52Z","timestamp":1775890852149,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374177"],"award-info":[{"award-number":["82374177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074137"],"award-info":[{"award-number":["82074137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetic nephropathy (DN) is a leading microvascular complication of diabetes, with limited effective treatments.\n                    <jats:italic>Cortex phellodendri<\/jats:italic>\n                    (CP), a traditional Chinese medicine known for its diverse chemical constituents, exhibits various pharmacological properties, including antibacterial and hypoglycemic effects. However, the precise mechanisms by which CP addresses DN remain unclear. This study explores the nephroprotective effects of CP in a type 2 diabetic mouse model induced by a high\u2010fat diet and streptozotocin. After 14 weeks of drug intervention, we assessed serum biomarkers (fasting blood glucose, total cholesterol, triglycerides, low\u2010density lipoprotein cholesterol, blood urea nitrogen, and serum creatinine) and urinary biomarkers (urea nitrogen, urinary creatinine, urinary albumin\u2010to\u2010creatinine ratio, and 24\u2010h urinary protein) in DN mice. Pharmacological results indicate that CP possesses the capacity to regulate disorders of glucose and lipid metabolism and improve renal dysfunction. We utilized ultra\u2010performance liquid chromatography\u2010high\u2010resolution tandem mass spectrometry to characterize the chemical constituents of CP and conducted a network pharmacology analysis on its plasma\u2010absorbed components. Histopathological examination of kidney sections was performed using hematoxylin\u2010eosin, Periodic acid\u2010schiff, and Masson staining. Additionally, Western blotting was used to detect proteins related to the AGEs\/RAGE axis. CP alleviates DN by inhibiting the AGEs\/RAGE pathway. This research seeks to provide a scientific foundation for the clinical application of CP in managing diabetic kidney disease.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502413","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:18:19Z","timestamp":1770981499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Cortex phellodendri<\/i>\n                    Exerts Its Nephroprotective Effect via the Inhibition of the AGEs\u2010RAGE Pathway"],"prefix":"10.1002","volume":"23","author":[{"given":"Ao","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine  Nanchang China"},{"name":"Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM and Engineering Technology Research Center for Chinese Materia Medica Quality of Guangdong Province Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Fan","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM and Engineering Technology Research Center for Chinese Materia Medica Quality of Guangdong Province Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua\u2010Ze","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM and Engineering Technology Research Center for Chinese Materia Medica Quality of Guangdong Province Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Yue","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM and Engineering Technology Research Center for Chinese Materia Medica Quality of Guangdong Province Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM and Engineering Technology Research Center for Chinese Materia Medica Quality of Guangdong Province Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Quan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Yan","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM and Engineering Technology Research Center for Chinese Materia Medica Quality of Guangdong Province Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-2220","authenticated-orcid":false,"given":"Dan","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine  Nanchang China"},{"name":"Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM and Engineering Technology Research Center for Chinese Materia Medica Quality of Guangdong Province Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115088"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010025\u201002700\u20100"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109083"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.10.035"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2023.101817"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2024.0317"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400910"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.119158"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153777"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.13852"},{"issue":"24","key":"e_1_2_12_13_1","first-page":"8664","article-title":"Research Progress on Antitumor Bioactive Compounds and Mechanisms of Phellodendri amurensis Cortex","volume":"55","author":"Bai L. L.","year":"2024","journal-title":"Chinese Traditional and Herbal Drugs"},{"issue":"05","key":"e_1_2_12_14_1","first-page":"478","article-title":"Research Progress on the Chemical Constituents and Pharmacological Effects of Phellodendri chinensis Cortex and Phellodendri amurensis Cortex","volume":"40","author":"Lu S. C.","year":"2023","journal-title":"Journal of Xinxiang Medical College"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7621929"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8498"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2008.41.10.710"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c03582"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116513"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14561"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.119129"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP091362"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.105990"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.729384"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14935"},{"issue":"05","key":"e_1_2_12_26_1","first-page":"673","article-title":"Effect of Phellodendrine on the Autophagy and Apoptosis of Lens Epithelial Cells Induced by High Glucose","volume":"60","author":"Li C. W.","year":"2024","journal-title":"Journal of Qingdao University"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfae233"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201801018"},{"issue":"04","key":"e_1_2_12_29_1","first-page":"330","article-title":"Analysis of Absorbed Components of Rhizoma Anemarrhenae\u2010Cortex phellodendri Chinesis Herb\u2010Pair Based on UPLC\u2010Q\u2010Exactive Orbitrap\u2010MS","volume":"59","author":"Xia T. L.","year":"2024","journal-title":"Chinese Pharmaceutical Journal"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3an36902a"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113215"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/wjtcm.wjtcm_34_23"},{"key":"e_1_2_12_33_1","article-title":"The Effectiveness of Antioxidant Agents in Delaying Progression of Diabetic Nephropathy: A Systematic Review of Randomized Controlled Trials","volume":"15","author":"Rahayu I.","year":"2025","journal-title":"Bioimpacts"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09\u20104171"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S250417"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.803874"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010020\u201009575\u20104"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1002710"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/403272"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.26599\/FSHW.2022.9250094"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2407"},{"issue":"05","key":"e_1_2_12_42_1","first-page":"548","article-title":"Mechanism of Compound Huangbai Liquid Liniment in Promoting Wound Tissue Healing in Diabetic Foot Ulcer Model Rats Based on AGEs\u2010bFGF Cross\u2010linking Pathway","volume":"44","author":"Xulin S. A. I.","year":"2025","journal-title":"Beijing Journal of Traditional Chinese Medicine"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111648"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7291434"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156104"},{"issue":"11","key":"e_1_2_12_46_1","first-page":"60","article-title":"Mechanism of Tangbikang Dry Paste in Prevention and Treatment of Type 2 Diabetic Peripheral Neuropathy Based on GLO\u20101\/AGE\/RAGE Pathway","volume":"31","author":"Lijia W. U.","year":"2025","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202502413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:32:23Z","timestamp":1775889143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202502413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/cbdv.202502413"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202502413","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02413"}}