{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:44Z","timestamp":1785484904854,"version":"3.56.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aims to evaluate the potential effects of\n                    <jats:italic>Omphalodes cappadocica<\/jats:italic>\n                    on a breast cancer cell line for the first time. The methanol extract of the aerial parts (Ae\u2010M) exhibited the strongest cytotoxicity against MCF\u20107 and MDA\u2010MB\u2010231 cells after 48\u00a0h of incubation, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 14.08\u00a0\u00b1\u00a00.05 and 10.63\u00a0\u00b1\u00a00.01\u00a0\u00b5g\/mL, respectively. The root methanol extract (Ro\u2010M) exhibited significant activity in the MCF\u20107 and MDA\u2010MB\u2010231 cell lines during 48\u00a0h of incubation, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 19.25\u00a0\u00b1\u00a00.66 and 16.38\u00a0\u00b1\u00a00.02\u00a0\u00b5g\/mL, respectively. Quantitative analysis by LC\u2013MS\/MS revealed that the main constituents of Ae\u2010M were rosmarinic, quinic, and vanillic acids. Quinic and fumaric acids were identified in Ro\u2010M. Quinic acid had a strong affinity for the target proteins PDB 3ERT, PDB 3HNG, and PDB 3KMU, with docking scores of \u22129.2, \u22127.8, and \u22126.6\u00a0kcal\/mol, respectively. The docking score for rosmarinic acid for the target protein PDB 3HNG was determined to be \u22129.7\u00a0kcal\/mol. The findings suggest that\n                    <jats:italic>O. cappadocica<\/jats:italic>\n                    may serve as a source for the development of anticancer agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502424","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:04:39Z","timestamp":1769191479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the Cytotoxic Potential of\n                    <i>Omphalodes cappadocica<\/i>\n                    (Willd.) DC. on Breast Cancer Cells by Phytochemical\u2010Based Molecular Docking Studies: A Comparative Study of Aerial Parts and Roots"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0803-2886","authenticated-orcid":false,"given":"\u0130\u00e7im","family":"G\u00f6kkaya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy Karadeniz Technical University  Trabzon T\u00fcrkiye"},{"name":"Institute of Health Sciences, Ankara University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceylan","family":"Hepokur","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Sivas Cumhuriyet University  Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okan","family":"Ayka\u00e7","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Inonu University  Malatya T\u00fcrkiye"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Sivas Cumhuriyet University  Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Karaman","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguz","family":"Cakir","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences Dicle University  Diyarbakir T\u00fcrkiye"},{"name":"Dicle University Science and Technology Research and Application Center  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Tarhan","sequence":"additional","affiliation":[{"name":"Dicle University Science and Technology Research and Application Center  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Abdullah","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Dicle University Science and Technology Research and Application Center  Diyarbakir T\u00fcrkiye"},{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Dicle University  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-0338","authenticated-orcid":false,"given":"G\u00fclin","family":"Renda","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","unstructured":"\u201cCancer Statistics \u201dGeneral Directorate of Public Health of Turkey accessed July 16 2024 https:\/\/hsgm.saglik.gov.tr\/tr\/kanser\u2010istatistikleri.html."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/16583655.2024.2354573"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2021.0459"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S336643"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659\u2010017\u20100140\u20109"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.21635"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.22038\/AJP.2019.13475"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.81847"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.105663"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2025.06.013"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13659\u2010020\u201000293\u20107"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238367"},{"key":"e_1_2_9_15_1","first-page":"1","article-title":"Two New Genera in the Omphalodes Group Cynoglosseae, Boraginaceae","volume":"23","author":"Serrano M.","year":"2016","journal-title":"Nova Acta Cient\u00edfica Compostelana"},{"key":"e_1_2_9_16_1","volume-title":"Flora of Turkey and the East Aegean Islands","author":"Davis P.","year":"1978"},{"key":"e_1_2_9_17_1","volume-title":"T\u00fcrkiye Bitkileri Listesi Damarl\u0131 Bitkiler","author":"G\u00fcner A.","year":"2012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.11646\/phytotaxa.498.4.2"},{"key":"e_1_2_9_19_1","unstructured":"Bizimbitkiler (2013) accessed September 30 2025 http:\/\/www.bizimbitkiler.org.tr."},{"key":"e_1_2_9_20_1","first-page":"1032","article-title":"Antimicrobial Activity and Volatile Constituents of Omphalodes cappadocica Willd. 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