{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:59:41Z","timestamp":1785085181145,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Colored rice has been reported to contain bioactive compounds. This study investigated the phytochemical composition, antioxidant, antibacterial, anti\u2010inflammatory, and cytotoxic properties of\n                    <jats:italic>Oryza sativa L. Cv<\/jats:italic>\n                    . MRQ 98 methanolic (M) and acetone (A) extracts, cultivated exclusively in Skuduk\u2010Chupak, Sarawak, Malaysia. HPLC analysis identified several phenolic acids in both free and bound fraction forms. The DPPH assay showed strong antioxidant activities, with maximal scavenging observed at 10\u00a0mg\/mL. Anti\u2010inflammatory activity showed more than 50% protection with extract concentrations lower than 2.5\u00a0mg\/mL. In contrast, antibacterial activity against\n                    <jats:italic>Cutibacterium acnes<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , and\n                    <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                    was weak, with IC\n                    <jats:sub>50<\/jats:sub>\n                    exceeding 10\u00a0mg\/mL. Cytotoxicity evaluation showed more than 90% cell viability at 0.3125\u20130.625\u00a0mg\/mL concentrations, decreasing to 77% viability at higher doses. In conclusion,\n                    <jats:italic>Oryza sativa L. Cv<\/jats:italic>\n                    . MRQ 98 extracts exhibited good antioxidant and anti\u2010inflammatory properties and were nontoxic; hence, their potential use for antiacne applications can further be explored.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502429","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:14:57Z","timestamp":1778696097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Bioactivities, Cytotoxicity, and Anti\u2010Acne Potential of Malaysian Colored Rice (\n                    <i>Oryza sativa L. Cv<\/i>\n                    . MRQ 98)"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2034-1465","authenticated-orcid":false,"given":"Intan","family":"Farahanah","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology Faculty of Pharmacy Universiti Teknologi Mara Puncak Alam Campus  Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-3608","authenticated-orcid":false,"given":"Shariza","family":"Sahudin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Faculty of Pharmacy Universiti Teknologi Mara Puncak Alam Campus  Selangor Malaysia"},{"name":"Elderly Medication and Research Group Faculty of Pharmacy Universiti Teknologi Mara Puncak Alam Campus  Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6815-3335","authenticated-orcid":false,"given":"Hannis Fadzillah","family":"Mohsin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Universiti Teknologi Mara Puncak Alam Campus  Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Alwani","family":"Ariffin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Life Sciences Faculty of Pharmacy Universiti Teknologi Mara Puncak Alam Campus  Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0578-0793","authenticated-orcid":false,"given":"Nur Ilyia Syazwani","family":"Saidin","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Health Campus Universiti Sains Malaysia  Kubang Kerian Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-3092","authenticated-orcid":false,"given":"Sabrina","family":"Ab Wahab","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Sungai Buloh Campus Universiti Teknologi Mara  Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.26538\/tjnpr\/v9i8.47"},{"key":"e_1_2_8_3_1","first-page":"125","article-title":"The Potential of MARDI Specialty Rice Varieties in the Development of Local Parboiled Rice","volume":"36","author":"Mhd Adnan A. 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