{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:08:36Z","timestamp":1775243316022,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","award":["104.01\u20102023.12"],"award-info":[{"award-number":["104.01\u20102023.12"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Nitric oxide (NO) is produced by both endothelial and neuronal cells and is involved in various biological processes, including vasodilation, neuromodulation, the immune response, and platelet aggregation. Excessive NO production can trigger the progression of pathological conditions, including inflammation and oxidative stress.\n                    <jats:italic>Lactuca indica<\/jats:italic>\n                    L. is a well\u2010known oriental medicinal plant used to treat several inflammatory diseases. To clarify the active ingredients thereof, four new compounds, (7\n                    <jats:italic>R<\/jats:italic>\n                    ,8\n                    <jats:italic>S<\/jats:italic>\n                    ,11\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010ferulin 15\n                    <jats:italic>\u2010O\u2010\u03b2\u2010<\/jats:italic>\n                    D\u2010glucopyranoside (\n                    <jats:bold>1<\/jats:bold>\n                    ), (2\n                    <jats:italic>R<\/jats:italic>\n                    ,3\n                    <jats:italic>R<\/jats:italic>\n                    )\u20102,3\u2010dihydro\u20102\u2010ethyl\u20103\u2010methylmaleimide N\n                    <jats:italic>\u2010\u03b2\u2010<\/jats:italic>\n                    D\u2010glucopyranoside (\n                    <jats:bold>2<\/jats:bold>\n                    ), 7S,7S,8R,8R\u2010(\u2010)\u2010neo\u2010olivil\u20104\n                    <jats:italic>\u2010O\u2010\u03b2\u2010<\/jats:italic>\n                    D\u2010glucopyranoside (\n                    <jats:bold>3<\/jats:bold>\n                    ), and (1\n                    <jats:italic>R<\/jats:italic>\n                    ,4\n                    <jats:italic>S<\/jats:italic>\n                    ,7\n                    <jats:italic>R<\/jats:italic>\n                    ,5\n                    <jats:italic>E<\/jats:italic>\n                    )\u20101,4\u2010dihydroxy\u2010germacra\u20105,10(14)\u2010diene (\n                    <jats:bold>4<\/jats:bold>\n                    ), and six known compounds (\n                    <jats:bold>5<\/jats:bold>\n                    \u2013\n                    <jats:bold>10<\/jats:bold>\n                    ) were isolated from the plant and their NO inhibitory activities evaluated. The chemical structures of the new compounds, including the absolute configurations, were fully determined via high\u2010resolution electrospray ionization mass spectrometry, nuclear magnetic resonance, and both experimental and time\u2010dependent density functional theory\u2010calculated electronic circular dichroism spectra. The new compounds and the known sesquiterpenoids were chemically diverse, major components of\n                    <jats:italic>L. indica<\/jats:italic>\n                    extracts. Compounds\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>10<\/jats:bold>\n                    potentially inhibit NO production (half\u2010maximal inhibitory concentration of 25.3 and 21.4\u00a0\u00b5M), suggesting that maleimide derivatives could serve as both therapeutic inhibitors and lead compounds for the discovery of anti\u2010inflammatory agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502438","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:55:20Z","timestamp":1760115320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Four New Compounds From\n                    <i>Lactuca indica<\/i>\n                    That Inhibit Nitric Oxide Production"],"prefix":"10.1002","volume":"22","author":[{"given":"Do Thi","family":"Trang","sequence":"first","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi","family":"Ha","sequence":"additional","affiliation":[{"name":"Drug, Cosmetic and Food Quality Control Center, Ha Tinh Province  Ha Tinh Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngo","family":"Anh Bang","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan Thi T.","family":"Huong","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Huy Hoang","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Viet Dung","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duong","family":"Thi Dung","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Thi Cuc","sequence":"additional","affiliation":[{"name":"Hanoi Irradiation Centre Vietnam Atomic Energy Institute, Ministry of Science and Technology of Vietnam  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham","family":"Hai Yen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui","family":"Huu Tai","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-6990","authenticated-orcid":false,"given":"Phan Van","family":"Kiem","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Medicinal Plants and Medicinal Animals in Vietnam","author":"Bich D. 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