{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:26Z","timestamp":1785484886856,"version":"3.56.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, we create novel imidazoles containing ciprofloxacin moieties that have demonstrated potent insecticidal activity. The synthesis was finished using a one\u2010pot method involving imidazoles\n                    <jats:bold>3a\u2013f<\/jats:bold>\n                    , formaldehyde, and ciprofloxacin. Furthermore, pyrazoles\n                    <jats:bold>11<\/jats:bold>\n                    and\n                    <jats:bold>12<\/jats:bold>\n                    were produced by the successful addition of benzothiazole and benzoxazole derivatives to the procedure. According to the data, all of the products that were tested demonstrated insecticidal efficacy against both\n                    <jats:italic>Spodoptera littoralis<\/jats:italic>\n                    larval instars, with adjustable levels. With LC\n                    <jats:sub>50<\/jats:sub>\n                    value of 4.55\u00a0mg\/L against larvae in their second instar, compound\n                    <jats:bold>6<\/jats:bold>\n                    was the most toxic of all. The target goods were tested on cotton leafworm larvae in their second and fourth instars. In an additional attempt to marginally expand insecticidal materials, the latent effects of the examined prepared materials were evaluated on a variety of biological parameters, including adult longevity, pupal weight, proportion of normal and deformed pupae, adult emergence, fecundity, and egg hatchability. Additionally, using compound\n                    <jats:bold>6<\/jats:bold>\n                    to treat the fourth\n                    <jats:italic>S. littoralis<\/jats:italic>\n                    larvae showed significant alterations in biochemical examination, including acetylcholinesterase, adenosine triphosphatase (ATPase), glutathione\n                    <jats:italic>S<\/jats:italic>\n                    \u2010transferase (GST), CaE, and total protein. These results provide insightful information about the continuous global search for more modern and efficient methods to manage insect resistance.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502449","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T08:59:33Z","timestamp":1769417973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel Approaching Imidazoles as Insecticidal Agents: Design, Synthesis, Toxicological, Biochemical, and Biological Effectiveness"],"prefix":"10.1002","volume":"23","author":[{"given":"Norah A.","family":"Alsaiari","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science and Art Najran University Najran Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer A.","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Sohag University  Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antar A.","family":"Abdelhamid","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science Al\u2010Baha University  Al\u2010Baha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobhi M.","family":"Gomha","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Islamic University of Madinah  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameera N.","family":"Al\u2010Ghamdi","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science Al\u2010Baha University  Al\u2010Baha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaf I.","family":"Alsenani","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science Al\u2010Baha University  Al\u2010Baha Saudi 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