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The biological evaluation of antiproliferative assay led to the discovery of compound\n                    <jats:bold>TA\u201016<\/jats:bold>\n                    with a highly potent cytotoxic effect using cervical, colon, liver and breast cancer cells, with IC\n                    <jats:sub>50<\/jats:sub>\n                    = 1.25\u00a0\u00b5M against MCF\u20107 cell. The mechanistic studies indicated the ability of\n                    <jats:bold>TA\u201016<\/jats:bold>\n                    in inducing apoptosis of MCF\u20107 cells through mitochondrial pathway and arresting the cell cycle at the G0\/G1 phase. It exhibited significant\n                    <jats:italic>anti<\/jats:italic>\n                    \u2010metastasis properties by inhibiting the expression of MMP\u20109 and MMP\u20102. Moreover, the cytotoxic study of compound\n                    <jats:bold>TA\u201016<\/jats:bold>\n                    on the MCF\u201010A, a normal human breast epithelial cell line, further highlighted the potential of compound\n                    <jats:bold>TA\u201016<\/jats:bold>\n                    as an anticancer agent for breast cancer with a selectivity index of 4.95. Molecular docking analyses confirmed the binding interaction between compound\n                    <jats:bold>TA\u201016<\/jats:bold>\n                    and its target proteins, validating its mechanism of action and potential as a therapeutic agent for breast cancer.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502457","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:15:15Z","timestamp":1773904515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, Molecular Docking, and Biological Evaluation of Tanshinone IIA Derivatives as Antibreast Cancer Agents"],"prefix":"10.1002","volume":"23","author":[{"given":"Shuai","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Mou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamin","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Anhui University of Science and Technology  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health Anhui University of Science and Technology  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-0247","authenticated-orcid":false,"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002297\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijc.ijc_83_21"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304\u2010017\u20100424\u20101"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2022.03.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdc.2023.101094"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jics.2022.100582"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003653134"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010017\u20100247\u20105"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100416"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000291"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12961"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2019.7294"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.05.012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920007780655450"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm2015292"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MD00642J"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2016.1157882"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01018"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66626-1_4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01259"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01153"},{"key":"e_1_2_9_24_1","volume-title":"The Practice of Medicinal Chemistry","author":"Wermuth C. 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